Lycopene (generic name)
treats Atherosclerosis, Ovarian cancer, Infertility, Coronary artery disease, High blood pressure associated with pregnancy, Lung function afte...
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This information is based on a professional level monograph edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Tracee Rae Abrams, PharmD (University of Rhode Island); Ernie-Paul Barrette, MD (MetroHealth Medical Center, Ohio); Ethan Basch, MD (Memorial Sloan-Kettering Cancer Center); Samuel Basch, MD (Mt. Sinai Medical Center, NY); Heather Boon, PharmD (University of Toronto); Wendy Chao, PhD (Natural Standard Research Collaboration); Benjamin Ebert, MD, PhD (Harvard Medical School); Nicole Giese, MS (Natural Standard Research Collaboration); Dana A. Hackman, BS (Northeastern University); Beth Kerbel, PharmD (Northeastern University); Philippe Szapary, MD (University of Pennsylvania); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Sarah Taylor, PharmD (University of Pittsburgh); Candy Tsourounis, PharmD (University of California, San Francisco); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Mamta Vora (Northeastern University); Wendy Weissner, BA (Natural Standard Research Collaboration).
BibliographyDISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Ansari MS, Gupta NP. A comparison of lycopene and orchidectomy vs. orchidectomy alone in the management of advanced prostate cancer. BJU Int 2003;92(4):375-378.
Bowen P, Chen L, Stacewicz-Sapuntzakis M, et al. Tomato sauce supplementation and prostate cancer: lycopene accumulation and modulation of biomarkers of carcinogenesis. Exp Biol Med (Maywood ) 2002;227(10):886-893.
Briviba K, Kulling SE, Moseneder J, et al. Effects of supplementing a low-carotenoid diet with a tomato extract for 2 weeks on endogenous levels of DNA single strand breaks and immune functions in healthy non-smokers and smokers. Carcinogenesis 2004;25(12):2373-2378.
Bunker CH, McDonald AC, Evans RW, et al. A randomized trial of lycopene supplementation in Tobago men with high prostate cancer risk. Nutr Cancer 2007;57(2):130-7.
Chandra RV, Prabhuji ML, Roopa DA, et al. Efficacy of lycopene in the treatment of gingivitis: a randomised, placebo-controlled clinical trial. Oral Health Prev Dent 2007;5(4):327-36.
Chong EW, Wong TY, Kreis AJ, et al. Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. BMJ 2007 Oct 13;335(7623):755.
Clark PE, Hall MC, Borden LS Jr, et al. Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse of prostate cancer after definitive local therapy. Urology 2006 Jun;67(6):1257-61.
Gianetti J, Pedrinelli R, Petrucci R, et al. Inverse association between carotid intima-media thickness and the antioxidant lycopene in atherosclerosis. Am Heart J 2002;143(3):467-474.
Giovannucci E, Rimm EB, Liu Y, et al. A prospective study of tomato products, lycopene, and prostate cancer risk. J Natl Cancer Inst 2002;94(5):391-398.
Gupta NP, Kumar R. Lycopene therapy in idiopathic male infertility--a preliminary report. Int Urol Nephrol 2002;34(3):369-372.
Jatoi A, Burch P, Hillman D, et al. A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: results of a Phase II study from the North Central Cancer Treatment Group. Urology 2007 Feb;69(2):289-94.
Kumar A, Bagewadi A, Keluskar V, et al. Efficacy of lycopene in the management of oral submucous fibrosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 Feb;103(2):207-13.
Schwarz S, Obermüller-Jevic UC, Hellmis E, et al. Lycopene inhibits disease progression in patients with benign prostate hyperplasia. J Nutr 2008 Jan;138(1):49-53.
Singh M, Krishanappa R, Bagewadi A, et al. Efficacy of oral lycopene in the treatment of oral leukoplakia. Oral Oncol 2004;40(6):591-596.
Vaishampayan U, Hussain M, Banerjee M, et al. Lycopene and soy isoflavones in the treatment of prostate cancer. Nutr Cancer 2007;59(1):1-7.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.