Lycopene (generic name)

treats Atherosclerosis, Ovarian cancer, Infertility, Coronary artery disease, High blood pressure associated with pregnancy, Lung function afte...
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Tradition

WARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

Dosing

Adults (18 years and older)

There is no proven effective medicinal dose of lycopene or lycopene-rich vegetables. A common dosing range is 2-30 milligrams of lycopene taken daily by mouth for up to six months. Commercially available products such as Lyc-O-Mato® and Lyco-O-Pen® have been studied for various conditions as have lycopene oleoresin capsules.

Children (younger than 18 years)

There is not enough scientific evidence to recommend the use of lycopene supplements in children.

Safety

DISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.

Allergies

Avoid lycopene in individuals with a known allergy/hypersensitivity to lycopene or tomatoes.

Side Effects and Warnings

The safety of lycopene supplements has not been thoroughly studied. Review of available scientific literature finds tomatoes, tomato-based products, and lycopene supplements generally well tolerated. However, rare reports of diarrhea, nausea, stomach pain or cramps, gas, vomiting, and loss of appetite have been reported. Tomatoes and tomato-based products may be acidic and irritate stomach ulcers. Lycopene has been associated with death from a cancer-related hemorrhage, although causality is unclear.

Pregnancy & Breastfeeding

There is not enough scientific research to recommend the use of lycopene supplements during pregnancy and breastfeeding. Amounts of lycopene found in foods are usually assumed to be safe. Tomato consumption has been shown to increase lycopene concentrations in breast milk and plasma of breastfeeding women.

Interactions

Interactions with Drugs

Some drugs that lower cholesterol levels in the blood may also reduce the levels of carotenoids such as lycopene. Examples of cholesterol-lowering drugs include "statin" drugs like lovastatin (Mevacor®) or atorvastatin (Lipitor®), cholestyramine (Questran®, Prevalite®, LoCHOLEST®), or colestipol (Cholestid®). It is unknown if replacing lycopene levels with supplements has any benefit in people using these drugs. Some research suggests that lycopene may add to the cholesterol-lowering effects of statin drugs.

It is proposed that nicotine (cigarette smoking) and alcohol may lower lycopene levels in the body, although this has not been proven.

Based on human study, tomato-based foods may prevent platelet aggregation and thrombosis. Theoretically, lycopene may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).

Lycopene may interact with drugs taken for cancer or high blood pressure. Lycopene may also interact with drugs that alter the body's immune response.

In theory, lycopene may interact with fertility treatments, but this potential interaction has not been thoroughly studied.

Interactions with Herbs and Dietary Supplements

Studies report mixed effects of taking lycopene with beta-carotene. Some studies report higher levels of lycopene, while others note no change or decreased levels. Canthaxanthin has been shown to reduce lycopene uptake from dietary sources and its use may result in decreased lycopene levels in the blood.

Laboratory studies suggest possible interactions between lycopene and other vitamins or supplements, although the significance of these interactions in the human body is not known. Examples include increased antioxidant effects when lycopene is combined with lutein or decreased growth of cancer-like cells when used with vitamin D or vitamin E.

Red palm oil may increase blood levels of lycopene.

Based on human study, tomato-based foods may prevent platelet aggregation and thrombosis. Theoretically, lycopene may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.

Lycopene may also interact with herbs or supplements taken for cancer, high blood pressure, or high cholesterol and those that alter the body's immune response.

It has been suggested that when lycopene and soy isoflavones are taken together, the potential benefits of both supplements may be negated.

In theory, lycopene may interact with herbs that affect fertility, but this potential interaction has not been thoroughly studied.

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