Liver Extract (generic name)

treats Hepatic disorders, Surgical uses, Chronic fatigue syndrome, Chronic hepatitis, and Pernicious anemia
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Interactions

Interactions with Drugs

Liver extract may increase gastric acid and pepsin outputs. Study results are unclear and caution is advised.

Liver extract may affect blood clotting and may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).

Liver extract may improve plasma cholesterol levels in patients with impaired hepatic function. Patients taking any cholesterol-lowering medications should use cautiously, as dosing adjustments may be necessary.

Liver extract may reversibly inhibit thymidine and uridine incorporation into DNA and RNA during cell growth and dose-dependently catalyze the removal of O6-methylguanine.

Liver extract may tend to normalize the metabolic clearance rate of human growth hormone in hepatopathic patients. Caution is advised in patients taking human growth hormones. Monitoring may be necessary

Liver extract inhibits lymphocyte proliferation. Caution is advised when combining liver extract with immunomodulating drugs.

Liver extract may increase the antiviral activity of interferon. It may also inhibit herpes simplex virus type-1 and influenza virus type A when used in combination with other antiviral agents.

Liver extract may have a high content of heme iron and antioxidant superoxide dismutase.

Interactions with Herbs and Dietary Supplements

Liver extract may increase gastric acid and pepsin outputs. Study results are unclear and caution is advised.

Liver extract may affect blood clotting, which may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.

Liver extract may improve plasma cholesterol levels in patients with impaired hepatic (liver) function. Patients taking any cholesterol-lowering herbs, such as red yeast rice, should use cautiously, as dosing adjustments may be necessary.

Liver extract may interact with herbs used as cancer therapies. Although not well studied in humans, caution is advised.

Liver extract may tend to normalize the metabolic clearance rate of human growth hormone in hepatopathic patients. Caution is advised in patients taking herbs or supplements similar to human growth hormones. Monitoring may be necessary.

Liver extract inhibits lymphocyte proliferation. Caution is advised when combining liver extract with immunomodulating herbs.

Liver extract may increase the antiviral activity of interferon. It may also inhibit herpes simplex virus type-1 and influenza virus type A when used in combination with other antiviral herbs.

Liver extract may have a high content of heme iron and antioxidant superoxide dismutase. Liver extract and vitamin B12 may have a therapeutic effect in patients with liver diseases and rheumatoid arthritis.

Attribution

This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ashley Brigham, PharmD (Northeastern University); J. Kathryn Bryan , BA (Natural Standard Research Collaboration ); James Ceurvels, PharmD (Northeastern University); Nicole Giese, MS (Natural Standard Research Collaboration); Juliann Goodfriend, PharmD (Northeastern University); Jason Mahoney, BA (Natural Standard Research Collaboration); Audrey Nealon, PharmD (Northeastern University); Rebecca Strauss, PharmD (Northeastern University); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Kenneth Triptow, PharmD (Drake University); Wendy Weissner, BA (Natural Standard Research Collaboration).

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