levocarnitine (generic name)

a nutraceutical product - treats Infertility, Arrhythmia, Exercise performance, Alzheimer's disease, Diabetic neuropathy, Peyronie's disease, C...
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Tradition

WARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Acidosis (acidemia), acne, anorexia, blood circulation, cocaine withdrawal, gonarthrosis (chronic wear of the cartilage in the knee joint), hypertension (high blood pressure), immunomodulator, macular degeneration, metabolic abnormalities (propionate), metabolic disorders (acquired total lipodystrophy), myocarditis/endocarditis (heart infections), neurologic disorders (children), retinal protection.

Dosing

Adults (18 years and older):

The U.S. Food and Drug Administration (FDA) recommends 1 gram of L-carnitine three times per day, intravenously (injected), for primary and secondary carnitine deficiency; this dose should not exceed 3 grams per day. A variety of doses have been used, with 3 grams per day in divided doses for 2-4 months being the most common; however, the doses range from 1 to 9 grams per day. Conditions treated have included AIDS, memory in alcoholics, Alzheimer's disease, angina (chest pain), congestive heart failure, depression, diabetes, diabetic neuropathy, dialysis, exercise performance, hepatic encephalopathy (brain disease), hyperlipidemia (high cholesterol), hyperthyroidism, myocardial infarction (heart attack), peripheral neuropathy (nerve damage), and peripheral vascular disease.

Intravenous (needle into a vein) injections have also been used, with doses typically ranging from 15-50 milligrams per kilogram twice daily. Injections have been given for seven days up to one year. Higher doses (up to 9 grams per day) have been studied. Injections should only be given under the supervision of a qualified healthcare professional.

Children (younger than 18 years):

The U.S. Food and Drug Administration (FDA) does not recommend exceeding 3 grams carnitine daily for primary and secondary carnitine deficiency. A typical dose for these deficiencies, as well as Rett's syndrome, is 100-200 milligrams per kilogram taken daily divided over two or three doses. For hyperlipidemia (high cholesterol), 3 grams L-carnitine for up to six weeks has been used. For total parental nutrition in infants, 50 micromoles per kilogram for two weeks has been used. Injections should only be given under the supervision of a qualified healthcare professional.

Safety

DISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.

Allergies

Avoid in individuals with a known allergy or hypersensitivity to carnitine.

Side Effects and Warnings

In general, L-carnitine is safe and no significant complications have been reported in available human clinical studies. Minor adverse effects have been reported with the use of L-carnitine or acetyl-L-carnitine, such as skin rash, body odor, "fishy smell," diarrhea, gastric pyrosis (heartburn), nausea, gastralgia (stomachache), loose bowel movement, nonspecific abdominal discomfort, or vomiting. Euphoria, insomnia, nervousness, mania, depression, and aggression have also been reported, but primarily in patients with pre-existing psychiatric conditions.

Transient hair loss was reported in 1% of cases. Less birth weight was regained in low birth weight infants treated with L-carnitine.

Carnitine supplements should be used cautiously in patients with peripheral vascular disease, hypertension (high blood pressure), alcohol-induced liver cirrhosis, low birth weight (infants), diabetics, and patients on hemodialysis.

Pregnancy and Breastfeeding

L-carnitine is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.

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