Gynostemma pentaphyllum (generic name)

treats Fatty liver and Cancer
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Interactions with Drugs

Although not well studied in humans, gypenosides extracted from Gynostemma pentaphyllum may have anticancer effects. Caution is advised when taking jiaogulan with other anticancer agents.

Gynostemma pentaphyllum may decrease serum triglyceride levels. Thus, caution is advised when combining jiaogulan with other cholesterol-lowering agents.

Gynostemma pentaphyllum may inhibit nuclear factor-kappaB activation, an important inflammatory factor. Caution is advised in patients taking anti-inflammatory agents.

Gynostemma pentaphyllum may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. However, current evidence is mixed. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).

Gynostemma pentaphyllum may decrease alanine aminotransferase, alkaline phosphatase, or aspartate aminotransferase levels in patients with nonalcoholic fatty liver disease. Caution is advised when combining jiaogulan with any potentially liver-damaging (hepatotoxic) agents.

Gynostemma pentaphyllum may decrease insulin levels and insulin index scores in patients with nonalcoholic fatty liver disease. Caution is advised when combining jiaogulan with diabetes agents.

Interactions with Herbs and Dietary Supplements

Although not well studied in humans, gypenosides extracted from Gynostemma pentaphyllum may have anticancer effects. Caution is advised when taking jiaogulan with other herbs or supplements that have potential anticancer effects.

Gynostemma pentaphyllum may decrease serum triglyceride levels. Thus, caution is advised when combining jiaogulan with other cholesterol-lowering herbs or supplements, such as red yeast rice.

Gynostemma pentaphyllum may inhibit nuclear factor-kappaB activation, an important inflammatory factor. Caution is advised in patients taking anti-inflammatory herbs or supplements.

Gynostemma pentaphyllum may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. However, current evidence is mixed. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.

Gynostemma pentaphyllum may decrease alanine aminotransferase, alkaline phosphatase, or aspartate aminotransferase levels in patients with nonalcoholic fatty liver disease. Caution is advised when combining jiaogulan with any potentially liver-damaging (hepatotoxic) herbs or supplements.

Gynostemma pentaphyllum may decrease insulin levels and insulin index scores in patients with nonalcoholic fatty liver disease. Caution is advised when combining jiaogulan with herbs or supplements taken to control blood sugar.

Attribution

This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): J. Kathryn Bryan, BA (Natural Standard Research Collaboration); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Nicole Giese, MS (Natural Standard Research Collaboration); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration).

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