iodine (generic name)

a minerals and electrolyte - treats Skin disinfectant/sterilization, Thyrotoxicosis / thyroid storm, Cognitive function, Septicemia, Postcesare...
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Interactions

Interactions with Drugs

Amiodarone (Cordarone®) contains significant amounts of iodine. Plasma iodine levels may be increased and additive with iodine supplements. Thyroid function should be monitored.

Concomitant use of angiotensin-converting enzyme inhibitors (ACE-I) or angiotensin receptor blockers (ARB) with potassium iodide increases the risk of hyperkalemia (high blood potassium levels). Examples of ACE inhibitors include benazepril (Lotensin®), captopril (Capoten®), enalapril (Vasotec®), fosinopril (Monopril®), lisinopril (Prinivil®, Zestril®), moexipril (Univasc®), perindopril (Aceon®), quinapril (Accupril®), ramipril (Altace®), and trandolapril (Mavik®). The ARBs include losartan (Cozaar®), valsartan (Diovan®), irbesartan (Avapro®), candesartan (Atacand®), telmisartan (Micardis®), and eprosartan (Teveten®).

Additive hypothyroid effects may occur with the use of iodine products in combination with antithyroid drugs (methimazole, propylthiouracil).

Additive hypothyroid effects may occur with the use of iodine products such as potassium iodide in combination with lithium salts. Lugol solution can increases lithium toxicity by inducing additive hypothyroid effects.

Concomitant use of potassium iodide with potassium-sparing diuretics may increase the risk of hyperkalemia (high blood potassium levels). Examples of potassium-sparing diuretics include spironolactone (Aldactone®), triamterene (Dyrenium®), and amiloride (Midamor®).

Interactions with Herbs and Dietary Supplements

Bugleweed (Lycopus virginicus/Lycopus europaeus) may reduce iodine uptake.

High iodine content can be found in kelp/seaweed/bladderwrack and may add to the effects of iodine supplementation.

Ingestion of lithospermum may lower thyroid hormone blood levels and may interact with the effects of iodine on thyroid hormone levels.

Selenium deficiency may exacerbate the effects of iodine deficiency.

Iodine may interact with herbs and supplements with diuretic effects; use cautiously.

Attribution

This information was edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ethan Basch, MD (Memorial Sloan-Kettering Cancer Center); Elizabeth Camacho, PharmD (University of Rhode Island); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Paul Hammerness, MD (Harvard Medical School); Catherine Meaghan McGrath, PharmD (University of Rhode Island); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Jen Woods, BS (Natural Standard Research Collaboration).

Bibliography

DISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

Aydingöz IE, Göktay F, Serdar ZA, et al. Iododerma following sitz bath with povidone-iodine. Australas J Dermatol 2007 May;48(2):102-4.

Cherry M, Daly CG, Mitchell D, et al. Effect of rinsing with povidone-iodine on bacteraemia due to scaling: a randomized-controlled trial. J Clin Periodontol 2007 Feb;34(2):148-55.

Gluck U, Martin U, Bosse B et al. A clinical study on the tolerability of a liposomal povidone-iodine nasal spray: implications for further development. ORL J Otorhinolaryngol Relat Spec 2007;69(2):92-9.

Hill J. Case of the month. Hyperthyroidism secondary to exogenous iodine intake. JAAPA. 2007 Sep;20(9):70.

Kara A, Tezer H, Devrim I, et al. Chemical burn: a risk with outdated povidone iodine. Pediatr Dermatol 2007 Jul-Aug;24(4):449-50.

Lowe DO, Knowles SR, Weber EA, et al. Povidone-iodine-induced burn: case report and review of the literature. Pharmacotherapy 2006 Nov;26(11):1641-5.

Madeb R, Feldman PA, Knopf J, et al. Povidone-iodine sclerotherapy is ineffective in the treatment of symptomatic renal cysts. J Endourol 2006 Jun;20(6):402-4.

Moudden MK, Labaye J, Sarret D, et al. [Acute renal failure following internal administration of povidone iodine: a case report]. Rev Med Interne 2007 Aug;28(8):556-8.

Nishimura C. Comparison of the antimicrobial efficacy of povidone-iodine, povidone-iodine-ethanol and chlorhexidine gluconate-ethanol surgical scrubs. Dermatology 2006;212 Suppl 1:21-5.

Ramirez-Ortiz MA, Rodriguez-Almaraz M, et al. Randomised equivalency trial comparing 2.5% povidone-iodine eye drops and ophthalmic chloramphenicol for preventing neonatal conjunctivitis in a trachoma endemic area in southern Mexico. Br J Ophthalmol 2007 Nov;91(11):1430-4.

Reed D. Third-degree burn by tincture of iodine--a case study. AAOHN J 2007 Oct;55(10):393-4.

Sato K, Ohmori T, Shiratori K, et al. Povidone iodine-induced overt hypothyroidism in a patient with prolonged habitual gargling: urinary excretion of iodine after gargling in normal subjects. Intern Med 2007;46(7):391-5.

Sobotka L, Smahelova A, Pastorova J, et al. A case report of the treatment of diabetic foot ulcers using a sodium hyaluronate and iodine complex. Int J Low Extrem Wounds 2007 Sep;6(3):143-7.

Vandergriff TW, Wasko CA, Schwartz MR, et al. Irritant contact dermatitis from exposure to povidone-iodine may resemble toxic epidermal necrolysis. Dermatol Online J 2006 Dec 10;12(7):12.

Wagenfeld L, Zeitz O, Richard G. Visual loss after povidone-iodine pleurodesis. N Engl J Med. 2007 Sep 20;357(12):1264-5.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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