Grapefruit Extract (generic name)

treats Atopic eczema, Endocrine disorders, Heart disease, and Kidney stones
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Average Ratings

Dosing

Adults (over 18 years old)

There is no proven effective dose for grapefruit. Grapefruit is typically taken as a fruit, seed extract, or pectin by mouth. It has also been applied on the skin as a disinfectant for skin wounds. For atopic eczema, 150 milligrams of grapefruit seed extract has been taken by mouth three times daily for one month. For heart disease, 15 grams of grapefruit pectin in divided doses with meals for 16 weeks has been used. For metabolic syndrome, grapefruit capsules, fresh grapefruit, or 8 oz. of grapefruit juice three times daily before each meal has been studied for 12 weeks.

Children (under 18 years old)

There is no proven effective dose for grapefruit in children. Grapefruit is likely safe when used in amounts commonly found in foods by individuals not on concurrent drug therapy.

Safety

DISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.

Allergies

Avoid in individuals with a known allergy or hypersensitivity to grapefruit.

Side Effects and Warnings

Grapefruit appears to be well-tolerated. Grapefruit is likely safe when used in amounts commonly found in foods by individuals not on concurrent drug therapy. Grapefruit has Generally Recognized as Safe (GRAS) status in the United States. Adverse effects from grapefruit juice have been reported only rarely and have been limited to those in combination with drug therapy. The severity of the interaction may depend on how much and how often the grapefruit juice is consumed, the timing of the grapefruit juice, the specific brand of juice, and the medication dose.

Experts report that topically applied grapefruit seed extract can be irritating to the skin.

High doses may cause pseudohyperaldosteronism (Liddle's syndrome), increases in potassium clearance, mineralocorticoid excess, lowered elevated hematocrits, the development of kidney stones, or increases in enamel loss and tooth surface loss.

Use cautiously in patients who drink red wine. Red wine in combination with grapefruit juice appears to have an additive inhibitory effect on the way liver breaks down some agents, theoretically increasing the risk for interactions with other drugs.

Use cautiously in patients who drink tonic water or smoke.

Use cautiously in patients with liver cirrhosis, at risk for kidney stones, or who have undergone gastric bypass surgery.

Pregnancy and Breastfeeding

Grapefruit is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.

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