ginkgo biloba (generic name)
an herbal product - treats Raynaud's disease, Diabetic neuropathy, Depression and seasonal affective disorder, Vitiligo, Vertigo, Mood and cogn...
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TraditionWARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Acidosis, aging, alcoholism, allergies, angina, anti-bacterial, anti-fungal, anti-inflammatory, antioxidant, anti-parasitic, anti-rheumatic, anti-tumor, anxiety, attention deficit hyperactivity disorder, autoimmune disorders, bladder disorders, blood vessel disorders, blood clots, body fat reducer (cellulite), brain damage, breast disease, breast tenderness, bronchitis, cancer, cataracts, chest pain, chilblains (inflammation of toes, fingers, ears, or face with exposure to cold), chronic rhinitis, colorectal cancer, congestive heart failure, cough, cyanosis, degenerative diseases (prevention), dermatitis, diabetes, digestion, dizziness, dysentery (bloody diarrhea), eczema, edema, encephalopathy (circulatory), fatigue, fibromyalgia, freckle-removing, genitourinary disorders, headache, heart attack, hepatitis B, high cholesterol, high blood pressure, hypoxia (lack of oxygen), immunomodulator, insomnia, labor induction, menstrual pain, migraine, mouth cancer, respiratory tract illnesses, scabies (ginkgo cream), seizures, sepsis, skin sores (ginkgo cream), spermicide, swelling, traumatic brain injury, ulcer (trophic lesions), ulcerative colitis, vaginal dryness, varicose veins, vision (color).
Adults (over 18 years old)
80 to 240 milligrams of a 50:1 standardized leaf extract taken daily by mouth in 2 to 3 divided doses has been used and studied (standardized to 24% to 25% ginkgo flavone glycosides and 6% terpine lactones). Other forms used include tea (bags usually contain 30 milligrams of extract), 3 to 6 milliliters of 40 milligrams per milliliter extract daily in three divided doses, and "fortified" foods. Ginkgo seeds are potentially toxic and should be avoided. The German ginkgo product Tebonin®, given through the veins (IV), was removed from the German market due to significant side effects.
Children (under 18 years old)
There is not enough scientific evidence to recommend use of ginkgo in children.
SafetyDISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.
Allergy/hypersensitivity to Ginkgo biloba or members of the Ginkgoaceae family may occur. A severe reaction called Stevens-Johnson syndrome, which includes skin blistering and sloughing-off, has been reported with use of a combination product. There may be cross-sensitivity to ginkgo in people allergic to urusiols (mango rind, sumac, poison ivy, poison oak, cashews), and an allergic cross-reaction has been reported in a person allergic to poison ivy.
Side Effects and Warnings
Overall, ginkgo leaf extract (used in most commercial products) appears to be well tolerated in most healthy adults at recommended doses for up to six months. Minor symptoms including headache, nausea, and intestinal complaints have been reported.
Bleeding has been associated with the use of ginkgo taken by mouth, and caution is advised in patients with bleeding disorders or taking drugs/herbs/supplements that may increase the risk of bleeding. Dosing adjustments may be necessary. Ginkgo should be stopped prior to some surgical or dental procedures. Reports of bleeding range from nose bleeds to life-threatening bleeding in several case reports. In some of these reports, ginkgo has been used with other agents that may also cause bleeding.
Eating the seeds is potentially deadly, due to risk of tonic-clonic seizures and loss of consciousness.
Based on human study, ginkgo may theoretically affect insulin and blood sugar levels. Caution is advised in patients with diabetes or hypoglycemia, and in those taking drugs, herbs, or supplements that affect blood sugar. Serum glucose levels may need to be monitored by a healthcare professional, and medication adjustments may be necessary.
There have been uncommon reports of dizziness, stomach upset, diarrhea, vomiting, muscle weakness, loss of muscle tone, restlessness, racing heart, rash, and irritation around the mouth with the use of ginkgo. There is a case report of "coma" in an elderly Alzheimer's patient taking trazodone and ginkgo, although it is not clear that ginkgo was the cause. Based on laboratory and human research, ginkgo may decrease blood pressure, although there is one report of ginkgo possibly raising blood pressure in a person taking a thiazide diuretic ("water pill"). Based on theory, high concentrations of ginkgo may reduce male and female fertility. Contamination with the drug colchicine has been found in commercial preparations of Ginkgo biloba.
Ginkgo may affect the outcome of electroconvulsive therapy (ECT). Adverse effects on the eyes have also been reported.
Pregnancy and Breastfeeding
Use of ginkgo is not recommended during pregnancy and breastfeeding due to lack of reliable scientific study in this area. The risk of bleeding associated with ginkgo may be dangerous during pregnancy.