bis-carboxyethyl germanium sesquioxide (generic name)

treats Multiple myeloma and Hepatitis B
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Tradition

WARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Amyloidosis (disease), analgesia, angina, antioxidant, antiviral, arteriosclerosis (hardening of arteries), arthritis, asthma, Behcet's disease, breast cancer, burns, cancer, cancer (intestinal), carcinoma (renal cell), cardiac abnormalities, cataracts, cerebral sclerosis, cervical cancer, chemotherapy (adjuvant), chronic fatigue syndrome, circulatory disorders, corns, depressive symptoms, detoxification, diabetes, digestion disorders, eczema, epilepsy, Epstein-Barr virus, eye diseases, gastritis, glaucoma, heart attack (acute myocardial infarction), heart disease, herpes, HIV/AIDS, hypertension (high blood pressure), immune stimulant, inflammation (retina and optic nerves), influenza, leukemia, lung cancer, lupus erythematosus, lymphoma, malaria, mental disorders, neuropathy, non-Hodgkin's lymphoma, osteoporosis, ovarian cancer, Parkinson's disease, prostate cancer, radiation toxicity, Raynaud's disease, rheumatoid arthritis, schizophrenia, skin eruptions, stress, tumors, ulcers, warts.

Dosing

Adults (over 18 years old)

There is no proven safe or effective dose for germanium. For cancer, intermittent administration of germanium sesquioxide (trade name: Ge-132) 1,000 milligrams has been shown to augment natural killer cell activity for up to ten days. For Epstein-Barr virus syndrome, 150-500 milligrams daily of Ge-132 (germanium sesquioxide) has caused marked symptom relief. For advanced malignant neoplasms, spirogermanium, one type of organogermanium, had limited and acceptable toxicity in utilizing a dose of 120 milligrams per m2 infused over two hours, three times weekly however, the benefits of this dosing remain unclear.

Children (under 18 years old)

There is no proven safe or effective dose for germanium, and use in children is not recommended.

Safety

DISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.

Allergies

Avoid in individuals with a known allergy or hypersensitivity to germanium. Skin rash occurred in a patient taking a germanium preparation (main component was germanium dioxide with some organic compound present). There have been no available reports of allergy to germanium sesquioxide, spirogermanium or other pure organogermanium compounds.

Side Effects and Warnings

Pure organic germanium (germanium sesquioxide, Ge-132) is possibly safe when used at recommended doses and monitored by a qualified healthcare professional, including a pharmacist. However, more study is needed to make a firm recommendation. To date, there have been no clinical trials studying germanium sesquioxide but one available case report indicated no side effects.

Most trials have been conducted on spirogermanium and have reported neurotoxicity and neurologic adverse effects; although there is at least one trial that has reported no adverse effects at all. Lethargy, dizziness, ataxia, lightheadedness, visual blurring, partial loss of taste, extreme weakness, ataxia, paresthesia, nausea and grand mal seizure have occurred. Rash and diarrhea have also been reported in patients taking spirogermanium, although it is unclear whether spirogermanium was the cause. There are relatively few reports of hepatic (liver) or renal (kidney) adverse effects with spirogermanium. However, hematologic (blood) toxicity and pulmonary (lung) toxicity have been observed in patients taking spirogermanium and 5-fluorouracil. Spirogermanium is likely unsafe when taken long-term or at high doses.

Depression was observed in two patients receiving propagermanium.

Peripheral neuropathy, anemia, kidney dysfunction, kidney tubular degeneration, myopathy (muscle disease), and germanium accumulation have occurred in those who ingested marketed organic germanium contaminated with germanium dioxide, carboxyethyl germanium sesquioxide, germanium lactate citrate, and/or unspecified forms. Avoid inorganic germanium products because of potential toxic effects. Also avoid ingesting organic germanium from unregulated sellers as it may be contaminated with toxic inorganic germanium.

Pregnancy & Breastfeeding

High doses of germanium may result in an increased embryonic resorption, but possible malformations have been reported only after administration of dimethyl germanium oxide (GeO2; inorganic germanium) to pregnant animals. Inorganic germanium should be avoided during pregnancy, and organic germanium is not recommended because of insufficient scientific evidence. Not recommended during breastfeeding due to insufficient available scientific evidence.

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