garlic (generic name)

an herbal product - treats Atherosclerosis, Heart attack prevention in patients with known heart disease, Anti-fungal, Familial hypercholestero...
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Interactions

Interactions with Drugs

Human reports suggest that garlic may increase the risk of bleeding when taken with drugs that also increase the risk of bleeding. Examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®). Animal and human studies show that garlic can lower blood pressure. Use cautiously when combining with other medications that lower blood pressure. Several human studies report lower cholesterol in people taking garlic. These effects may be increased if garlic is taken with medications that lower blood cholesterol like lovastatin (Mevacor®) or other "statins" (HMGCoA reductase inhibitors).

Levels of the drug saquinavir, used in HIV treatment, may be reduced if garlic is taken, and its effectiveness may therefore be reduced. Other antiviral drugs like ritonavir may also be affected.

Garlic may lower blood sugar levels. Although this is theoretical in humans, caution is advised when using medications that may also lower blood sugar. Patients taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional. Medication adjustments may be necessary. Individuals with thyroid disorders or who take thyroid medications should use caution in taking garlic supplements as they may affect the thyroid.

Garlic may alter levels of certain drugs metabolized by the liver's CYP450 enzyme system.

Many tinctures contain high levels of alcohol, and may cause nausea or vomiting when taken with metronidazole (Flagyl®) or disulfiram (Antabuse®).

Garlic may alter levels of various anti-cancer drugs. Check with your oncologist and pharmacist before starting to take garlic supplements.

Interactions with Herbs and Dietary Supplements

Garlic may increase the risk of bleeding. In theory, this risk may be further increased when garlic is taken with other herbs or supplements that also increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba and two cases with saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.

Vitamin E may have positive effects on cardiovascular disease and atherosclerosis. Taking garlic with vitamin E may increase these effects.

Garlic may have a small effect in lowering blood pressure. Caution should be used if taken with other supplements that can lower blood pressure.

Garlic may lower blood sugar levels. Caution is advised when using herbs or supplements that may also lower blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.

Garlic may lower cholesterol a small amount. These effects may be larger than expected if taken with other cholesterol-lowering supplements such as fish oil. Individuals with thyroid disorders or who take thyroid medications should use caution in taking garlic supplements as they may affect the thyroid.

Garlic may interact with herbals and dietary supplements that are metabolized by the liver's CYP450 enzyme system.

Garlic and pycnogenol have been shown to increase human growth hormone secretion in laboratory experiments.

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