gamma-oryzanol (generic name)

treats Bodybuilding, Hyperlipidemia, Menopausal symptoms, Hypothyroidism, Gastritis, and Skin conditions and prevents Prevention of restenosis ...
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Although not well studied in humans, oryzanol combined with a high cholesterol diet may increase the risk of bleeding. Gamma oryzanol has also shown significant cholesterol-lowering effects. Caution is advised when taking gamma oryzanol with other cholesterol-lowering agents due to additive effects.

In pharmacological tests, cycloartenol ferulic acid ester, a component of gamma oryzanol, may have a suppressant effect on the central nervous system; its properties seemed different from those of existing major and minor tranquilizers.

Although not well studied in humans, gamma oryzanol may suppress growth hormone synthesis, prolactin release, and luteinizing hormone release.

Gamma oryzanol may increase insulin sensitivity in diabetics. Patients taking insulin or agents that alter blood sugar levels should use gamma oryzanol with caution. Dosing adjustments may be necessary.

Gamma oryzanol may moderately stimulate the immune system and caution is advised in patients taking immunomodulating agents.

Gamma oryzanol may reduce thyroid-stimulating hormone (TSH) in patients with hypothyroidism.

Interactions with Herbs & Dietary Supplements

Although not well studied in humans, oryzanol combined with a high cholesterol diet may increase the risk of bleeding. Caution is advised.

In pharmacological tests, cycloartenol ferulic acid ester, a component of gamma oryzanol, may have a suppressant effect on the central nervous system; its properties seemed different from those of existing major and minor tranquilizers.

Although not well studied in humans, gamma oryzanol may increase insulin sensitivity in diabetics. Patients using herbs that alter blood sugar levels should use gamma oryzanol with caution. Dosing adjustments may be necessary.

Gamma oryzanol may moderately stimulate the immune system. Caution is advised in patients taking immunomodulating herbs due to possible additive effects.

Gamma oryzanol may reduce thyroid stimulating hormone (TSH) in patients with hypothyroidism.

Attribution

This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Tracee Rae Abrams, PharmD (University of Rhode Island); Jessica Clubb, PharmD (Northeastern University); Antoinette Edmondson, PharmD (Massachusetts College of Pharmacy); Nicole Giese, MS (Natural Standard Research Collaboration); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration).

Bibliography

DISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

Accinni R, Rosina M, Bamonti F, et al. Effects of combined dietary supplementation on oxidative and inflammatory status in dyslipidemic subjects. Nutr Metab Cardiovasc.Dis. 2006;16(2):121-127.

Arai T. [Effect of gamma-oryzanol on indefinite complaints in the gastrointestinal symptoms in patients with chronic gastritis--studies on the endocrinological environment (author's transl)]. Horumon To Rinsho 1982;30(3):271-279.

Berger A, Rein D, Schafer A, et al. Similar cholesterol-lowering properties of rice bran oil, with varied gamma-oryzanol, in mildly hypercholesterolemic men. Eur J Nutr 2005;44(3):163-173.

Chen CW, Cheng HH. A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes. J Nutr 2006;136(6):1472-1476.

Hayakawa R. Clinical evaluation of FC-9201 cream containing 1.0% gamma-oryzanol. Skin Research 1993;35(1):131-154.

Juliano C, Cossu M, Alamanni MC, et al. Antioxidant activity of gamma-oryzanol: mechanism of action and its effect on oxidative stability of pharmaceutical oils. Int J Pharm 8-11-2005;299(1-2):146-154.

Miller A, Engel KH. Content of gamma-oryzanol and composition of steryl ferulates in brown rice (Oryza sativa L.) of European origin. J Agric.Food Chem 10-18-2006;54(21):8127-8133.

Most MM, Tulley R, Morales S, et al. Rice bran oil, not fiber, lowers cholesterol in humans. Am J Clin Nutr 2005;81(1):64-68.

Ng SS, Figg WD. Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice. Anticancer Res 2003;23(5A):3585-3590.

Parrado J, Miramontes E, Jover M, et al. Prevention of brain protein and lipid oxidation elicited by a water-soluble oryzanol enzymatic extract derived from rice bran. Eur J Nutr 2003;42(6):307-314.

Sierra S, Lara-Villoslada F, Olivares M, et al. Increased immune response in mice consuming rice bran oil. Eur J Nutr 2005;44(8):509-516.

Suh MH, Yoo SH, Chang PS, et al. Antioxidative activity of microencapsulated gamma-oryzanol on high cholesterol-fed rats. J Agric.Food Chem 12-14-2005;53(25):9747-9750.

Umehara K, Shimokawa Y, Miyamoto G. Effect of gamma-oryzanol on cytochrome P450 activities in human liver microsomes. Biol Pharm Bull 2004;27(7):1151-1153.

Wheeler KB, Garleb KA. Gamma oryzanol-plant sterol supplementation: metabolic, endocrine, and physiologic effects. Int J Sport Nutr 1991;1(2):170-177.

Wilson TA, Nicolosi RJ, Woolfrey B, et al. Rice bran oil and oryzanol reduce plasma lipid and lipoprotein cholesterol concentrations and aortic cholesterol ester accumulation to a greater extent than ferulic acid in hypercholesterolemic hamsters. J Nutr Biochem 5-16-2006;

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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