gamma-Linolenic Acid (generic name)
treats Pruritus, Immune enhancement, Ulcerative colitis, Diabetic neuropathy, Attention deficit hyperactivity disorder, Osteoporosis, Menopausa...
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Interactions with Drugs
GLA may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).
Theoretically, GLA may increase the effectiveness of ceftazidime, an antibiotic in a class known as cephalosporins, against a variety of bacterial infections. It is unknown whether effectiveness of other cephalosporin antibiotics are likewise affected.
GLA may alter the effects of certain anti-cancer treatments. Caution is advised.
Theoretically, taking omega-6 fatty acids, such as GLA, during therapy with cyclosporine, a medication used to suppress the immune system after an organ transplant, for example, may increase the immunosuppressive effects of cyclosporine and may protect against kidney damage associated with cyclosporine.
Individuals taking phenothiazines (such as chlorpromazine, fluphenazine, perphenazine, promazine, and thioridazine) to treat schizophrenia should not take evening primrose oil, a source of GLA, because it may interact with these medications and increase the risk of seizures. Theoretically, the same may be true for other GLA containing supplements.
Interactions with Herbs and Dietary Supplements
GLA may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.
Although not well studied in humans, coenzyme Q10 and vitamin E reversed the inhibition of cell growth associated with GLA. Thus, nutritional antioxidants may inhibit certain effects associated with GLA.
This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Julie Conquer, PhD (RGB Consulting); Catherine DeFranco Kirkwood, MPH, CCCJS-MAC (MD Anderson Cancer Center); Dana A. Hackman, BS (Northeastern University); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Shannon Welch, PharmD (Northeastern University); Jen Woods, BS (Northeastern University); Edward Yost (Northeastern University).
BibliographyDISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
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