cranberry (generic name)

an herbal product - treats Achlorhydria and B12 absorption, Urostomy care, Urinary tract infection, Urine acidification, H. Pylori infection, M...
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Interactions with Drugs

In theory, due to its acidic pH, cranberry juice may counteract antacids. Cranberry juice theoretically may increase the effects of antibiotics in the urinary tract and increase the excretion of some drugs in the urine. Cranberry juice may increase absorption of vitamin B12 in patients using proton pump inhibitors such as esomeprazole (Nexium®).

Some cranberry tinctures may have high alcohol content and may lead to vomiting if used with the drug disulfiram (Antabuse®) or metronidazole (Flagyl®).

Although controversial, some studies have shown that taking the prescription blood thinner warfarin (Coumadin®) and cranberry products at the same time can elevate the INR, which could increase the risk of bleeding.

Alzheimer's drugs, anthelmintics (expel worms), antifungals, cholesterol-lowering drugs, antineoplastics (anticancer agents), antiprotozoals, antiviral agents, clarithromycin, drugs broken down by the liver, diuretics, salicylates like aspirin, and drugs eliminated by the kidneys may interact with cranberry.

Interactions with Herbs and Dietary Supplements

In theory, cranberry juice may increase the excretion of some herbs or supplements in the urine.

Theoretically cranberry products may increase the risk of bleeding in people taking other herbs or supplements like garlic or danshen.

Inhibition of H. pylori bacteria, which may lead to gastrointestinal ulcers, may be increased when oregano and cranberry are taken together.

Alzheimer's herbs and supplements, antacids, anthelminthics (expel worms), antibacterials, antifungals, cholesterol-lowering herbs and supplements, antineoplastics, antioxidants, antiparasitics, antivirals, herbs and supplements broken down by the liver, diuretics, lingonberry, salicylate-containing herbs like willow bark, urine-acidifying herbs and supplements, and vitamin B12 may interact with cranberry.


This patient information is based on a professional level monograph edited and peer-reviewed by contributors to the Natural Standard Research Collaboration ( Imtiaz Ahmad, MD (Harvard School of Public Health); Ethan Basch, MD (Memorial Sloan-Kettering Cancer Center); Samuel Basch, MD (Mt. Sinai Medical Center, NY); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Edzard Ernst, MD, PhD (University of Exeter); Paul Hammerness, MD (Massachusetts General Hospital); Sadaf Hashmi, MD, MPH (Johns Hopkins School of Hygiene and Public Health); Michael Smith, M.R.PharmS, ND (Canadian College of Naturopathic Medicine); David Sollars, M.Ac, H.M.C. (New England School of Acupuncture); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Deborah Wexler, MD (Harvard Medical School).


DISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to Selected references are listed below.

Bailey DT, Dalton C, Joseph Daugherty F, et al. Can a concentrated cranberry extract prevent recurrent urinary tract infections in women? A pilot study. Phytomedicine 2007 Apr;14(4):237-41.

Campbell G, Pickles T, D'yachkova Y. A randomised trial of cranberry versus apple juice in the management of urinary symptoms during external beam radiation therapy for prostate cancer. Clin Oncol (R Coll Radiol) 2003;15(6):322-328.

Chambers BK, Camire ME. Can cranberry supplementation benefit adults with type 2 diabetes? Diabetes Care 2003 Sep;26(9):2695-6.

Crews WD Jr, Harrison DW, Griffin ML, et al. A double-blinded, placebo-controlled, randomized trial of the neuropsychologic efficacy of cranberry juice in a sample of cognitively intact older adults: pilot study findings. J Altern Complement Med 2005 Apr;11(2):305-9.

Elliott SP, Villar R, Duncan B. Bacteriuria management and urological evaluation of patients with spina bifida and neurogenic bladder: a multicenter survey. J Urol 2005 Jan;173(1):217-20.

Gettman MT, Ogan K, Brinkley LJ, et al. Effect of cranberry juice consumption on urinary stone risk factors. J Urol 2005 Aug;174(2):590-4; quiz 801.

Grant P. Warfarin and cranberry juice: an interaction? J Heart Valve Dis 2004 Jan;13(1):25-6.

Howell AB, Foxman B. Cranberry juice and adhesion of antibiotic-resistant uropathogens. JAMA 2002;287(23):3082-3083.

Jepson RG, Craig JC. A systematic review of the evidence for cranberries and blueberries in UTI prevention. Mol Nutr Food Res 2007 Jun;51(6):738-45.

Kontiokari T, Salo J, Eerola E, et al. Cranberry juice and bacterial colonization in children--a placebo-controlled randomized trial. Clin Nutr 2005 Dec;24(6):1065-72.

Kontiokari T, Sundqvist K, Nuutinen M, et al. Randomised trial of cranberry-lingonberry juice and Lactobacillus GG drink for the prevention of urinary tract infections in women. BMJ 2001;322(7302):1571-1573.

Linsenmeyer TA, Harrison B, Oakley A, et al. Evaluation of cranberry supplement for reduction of urinary tract infections in individuals with neurogenic bladders secondary to spinal cord injury. A prospective, double-blinded, placebo-controlled, crossover study. J Spinal Cord Med 2004;27(1):29-34.

Shmuely H, Yahav J, Samra Z, et al. Effect of cranberry juice on eradication of Helicobacter pylori in patients treated with antibiotics and a proton pump inhibitor. Mol Nutr Food Res. 2007 Jun;51(6):746-51.

Waites KB, Canupp KC, Armstrong S, et al. Effect of cranberry extract on bacteriuria and pyuria in persons with neurogenic bladder secondary to spinal cord injury. J Spinal Cord Med 2004;27(1):35-40.

Zhang L, Ma J, Pan K, et al. Efficacy of cranberry juice on Helicobacter pylori infection: a double-blind, randomized placebo-controlled trial. Helicobacter 2005 Apr;10(2):139-45.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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