clove (generic name)

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Interactions

Interactions with Drugs

Based on laboratory research, clove theoretically may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. It is not clear what doses or methods of using clove may increase this risk. Some examples of drugs that increase bleeding risk include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix), and non-steroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).

Clove oil taken by mouth may lower blood sugar levels. Caution is advised when using medications that may also lower blood sugar. Patients taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare provider. Medication adjustments may be necessary.

When applied to the skin, eugenol, a component of clove, may reduce the ability to feel and react to painful stimulation. Therefore, use of clove products on the skin with other numbing or pain-reducing products such as lidocaine/prilocaine cream (Emla®) theoretically may increase effects.

Clove may also react with antifungals, anti-inflammatories, antihistamines, antineoplastics, and drugs taken for cardiovascular conditions. Clove may also affect the way in which the liver breaks down certain drugs.

Interactions with Herbs and Dietary Supplements

Based on laboratory research, clove may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. It is not clear what doses or methods of using clove may increase this risk. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, some cases with garlic, and fewer cases with saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.

Clove may lower blood sugar levels. Caution is advised when using herbs or supplements that may also lower blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.

When applied to the skin, eugenol, a component of clove, may reduce the ability to feel and react to painful stimulation. Therefore, use with other numbing or pain-reducing products such as capsaicin cream (Zostrix®) may in theory cause exaggerated effects.

Clove may also react with anti-inflammatory, antifungal, antihistamine, and antineoplastic herbs, and herbs taken for cardiovascular conditions. Clove may also affect the way in which the liver breaks down certain herbs.

Attribution

This information is based on a professional level monograph edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ethan Basch, MD (Memorial Sloan-Kettering Cancer Center); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Anait Gasparyan, PharmD (Northeastern University); Nicole Giese, MS (Natural Standard Research Collaboration); Sadaf Hashmi, MD, MPH (Johns Hopkins School of Hygiene and Public Health); Jenna Hollenstein, MS, RD (Natural Standard Research Collaboration); Michelle Miranda, PharmD (University of Rhode Island); David Sollars MAc, HMC (New England School of Acupuncture); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Mamta Vora, PharmD (Northeastern University); Wendy Weissner, BA (Natural Standard Research Collaboration).

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