Borago officinalis (generic name)

treats Periodontitis / gingivitis, Supplementation in preterm and very low birthweight infants, Hyperlipidemia, Alcohol-induced hangover, Asthm...
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Interactions with Drugs

Borage may have antibacterial effects against Helicobacter pylori. Use cautiously with antibiotics and antiulcer medications due to possible additive effects.

Borage may increase the risk of bleeding, especially when taken with drugs that increase the risk of bleeding, such as warfarin therapy.

Preliminary evidence suggests that borage may lower the seizure threshold. Use cautiously in patients with seizures or taking anticonvulsant medications.

Preliminary evidence suggests that borage oil may have anti-inflammatory properties. Use cautiously with anti-inflammatory medications due to possible additive effects.

Although not well studied in humans, gamma linolenic acid may decrease plasma triglyceride levels and may increase HDL-cholesterol concentration. Use cautiously in patients taking cholesterol-lowering medications due to possible additive effects.

Borage oil may alter heart function. Use cautiously in patients with heart conditions or taking cardiovascular medications.

Preliminary evidence suggests that gamma linolenic acid may alter immune responses. Use cautiously with other immunomodulators.

Concomitant nonsteroidal anti-inflammatory (NSAID) drug use may undermine borage oil effects; use cautiously.

Interactions with Herbs and Dietary Supplements

Although not well studied in humans, borage may have antibacterial effects against Helicobacter pylori. Use cautiously with herbs and supplement that may have antibacterial or antiulcer activity.

Preliminary evidence suggests that borage seed oil may potentially increase the risk of bleeding or potentiate the effects of warfarin therapy. Use cautiously with bleeding disorders or with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto.

Preliminary evidence suggests that borage may lower the seizure threshold. Use cautiously in patients with seizures or taking anticonvulsant herbs or supplements.

Preliminary evidence suggests that borage oil may have anti-inflammatory properties. Use cautiously with anti-inflammatory herbs or supplements due to possible additive effects.

Although not well studied in humans, gamma linolenic acid may decrease plasma triglyceride levels and may increase HDL-cholesterol concentration. Use cautiously in patients taking cholesterol-lowering herbs, such as red yeast rice, due to possible additive effects.

Borage oil may alter heart function. Use cautiously in patients with heart conditions or taking cardiovascular herbs or supplements.

Preliminary evidence suggests that gamma linolenic acid may alter immune responses. Use cautiously with other immunomodulators.

Attribution

This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Nicole Giese, MS (Natural Standard Research Collaboration); J. Kathryn Bryan, BA (Natural Standard Research Collaboration); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration).

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