Berberine (generic name)
treats Infectious diarrhea, Heart failure, Thrombocytopenia, Glaucoma, Parasitic infection, H. pylori infection, Hypercholesterolemia, Chloroqu...
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Authors/Editors: Julie Conquer, PhD (RGB Consulting); Nicole Giese, MS (Natural Standard Research Collaboration); Helena Kim, PharmD (Northeastern University); Thuy-Duong Le, PharmD (Oregon State University); Mary McGarry, RPh (University of Kansas); Todd Porter, PharmD (University of Kentucky); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Mamta Vora, PharmD (Northeastern University); Wendy Weissner, BA (Natural Standard Research Collaboration); Jen Woods BS (Northeastern University).
BibliographyDISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Abidi P, Zhou Y, Jiang JD, et al. Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine. Arterioscler.Thromb.Vasc.Biol 2005;25(10):2170-2176.
Doggrell SA. Berberine--a novel approach to cholesterol lowering. Expert.Opin.Investig.Drugs 2005;14(5):683-685.
Hsiang CY, Wu SL, Cheng SE, et al. Acetaldehyde-induced interleukin-1beta and tumor necrosis factor-alpha production is inhibited by berberine through nuclear factor-kappaB signaling pathway in HepG2 cells. J Biomed.Sci 2005;12(5):791-801.
Inoue K, Kulsum U, Chowdhury SA, et al. Tumor-specific cytotoxicity and apoptosis-inducing activity of berberines. Anticancer Res 2005;25(6B):4053-4059.
Kettmann V, Kosfalova D, Jantova S, et al. In vitro cytotoxicity of berberine against HeLa and L1210 cancer cell lines. Pharmazie 2004;59(7):548-551.
Kim HR, Min HY, Jeong YH, et al. Cytotoxic constituents from the whole plant of Corydalis pallida. Arch Pharm Res 2005;28(11):1224-1227.
Kim JS, Tanaka H, Shoyama Y. Immunoquantitative analysis for berberine and its related compounds using monoclonal antibodies in herbal medicines. Analyst 2004;129(1):87-91.
Kong W, Wei J, Abidi P, et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med 2004;10(12):1344-1351.
Kuo CL, Chi CW, Liu TY. Modulation of apoptosis by berberine through inhibition of cyclooxygenase-2 and Mcl-1 expression in oral cancer cells. In Vivo 2005;19(1):247-252.
Lin CC, Kao ST, Chen GW, et al. Berberine decreased N-acetylation of 2-aminofluorene through inhibition of N-acetyltransferase gene expression in human leukemia HL-60 cells. Anticancer Res 2005;25(6B):4149-4155.
Lin CC, Kao ST, Chen GW, et al. Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3. Anticancer Res 2006;26(1A):227-242.
Lin JP, Yang JS, Lee JH, et al. Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line. World J Gastroenterol. 1-7-2006;12(1):21-28.
Mantena SK, Sharma SD, Katiyar SK. Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells. Mol Cancer Ther 2006;5(2):296-308.
Quan H, Cao YY, Xu Z, et al. Potent in vitro synergism of fluconazole and berberine chloride against clinical isolates of Candida albicans resistant to fluconazole. Antimicrob.Agents Chemother. 2006;50(3):1096-1099.
Wu X, Li Q, Xin H, Yu A, et al. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61(8):567-572.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.