These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Heavy metal/lead toxicity:
For many years, chelation therapy has been used with calcium disodium EDTA to treat heavy metal poisoning. It is still an accepted medical therapy for lead toxicity, and several studies report lower levels of lead in the blood and slower progression of kidney failure. Chelation therapy may also be used to treat iron, arsenic, mercury, or cobalt poisoning. However, some research results are mixed. More studies are needed to clarify.
Repeated chelation therapy may improve kidney function and slow the progression of kidney damage. Further research is needed to confirm these results.
Eye disorders (calcific band keratopathy):
EDTA is use to treat calcium deposits on the eye. However, well-designed research is needed before a recommendation can be made.
Ovarian cancer (used with chemotherapy):
Early evidence shows that EDTA may be beneficial in ovarian cancer patients when used with chemotherapy. However, further studies are needed before a strong recommendation can be made.
Evidence does not support the use of EDTA chelation therapy in heart disease even though there is strong popular interest in this use. At this time, the evidence suggests it does not work and it cannot be recommended as a treatment for heart disease.
Claudication (peripheral vascular disease):
People with clogged arteries in the legs (peripheral vascular disease) may experience a sensation of pain or fatigue in the legs with exercise (claudication). Studies suggest that EDTA chelation therapy may not be beneficial in claudication and this use is not supported by research at this time.
The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below. Alzheimer's disease, anemia, arthritis, autism, blood disorders, blood pressure, cataracts, chronic obstructive pulmonary disease (COPD), degenerative diseases (chronic), dementia, diabetes, digoxin toxicity, disease diagnosis, emphysema, encephalopathy, gallstones, gout, heart rhythm abnormalities, hemochromatosis, keratitis (inflammation of the cornea of the eye), macular degeneration, memory loss, neurodegenerative disorders, neuroprotection (oxaliplatin-related toxicity), osteoarthritis, osteoporosis, Parkinson's disease, rheumatoid arthritis, scleroderma, sexual development, sickle-cell disease, snakebites, stroke, systemic lupus erythematosus, vision problems, Wilson's disease.