Is a Partial Thromboplastin Time (PTT) Test?
A partial thromboplastin time (PTT) test is a blood test that helps
doctors assess your body’s ability to form blood clots.
Bleeding triggers a series of reactions known as the coagulation
cascade. Coagulation is the process your body uses to stop blood loss. Cells
called platelets create a plug to cover the damaged tissue. Then your body’s
clotting factors interact to produce a blood clot. Low levels of clotting factors
can prevent a clot from forming. Factor deficiency can lead to symptoms such as
excessive bleeding, persistent nosebleeds, and easy bruising.
To test your body’s blood clotting abilities, your doctor will
collect a sample of your blood in a vial and add chemicals. The test measures
how many seconds it takes for your blood to clot after the addition of the
This test is sometimes known as an activated partial
thromboplastin time (APTT) test.
Do I Need a PTT Test?
Your doctor may order a PTT test to investigate the cause of
prolonged or excessive bleeding. Symptoms that may prompt your doctor to order
this test include:
- frequent or heavy nosebleeds
- heavy or prolonged menstrual periods
- blood in the urine
- swollen and painful joints (caused by bleeding
into your joint spaces)
- easy bruising
The PTT test can’t diagnose a specific condition. Instead, it
helps your doctor figure out whether your blood clotting factors may be
deficient. If your test results are abnormal, your doctor will probably need to
order more tests to figure out which factor your body isn’t producing.
Your doctor might also use this test to monitor your condition if
you’re taking the blood thinner heparin.
Do I Prepare for a PTT Test?
Several medications can affect the results of a PTT test. These
- vitamin C
Make sure you tell your doctor about all the medications you
take. You may need to stop taking them before the test.
Are the Risks Associated with a PTT Test?
As with any blood test, there’s a slight risk of bruising,
bleeding, or infection at the puncture site. In rare cases, the vein may become
swollen after a blood draw. This condition is known as phlebitis. Applying a
warm compress several times a day can treat phlebitis.
Ongoing bleeding could be a problem if you suffer from a bleeding
disorder or are taking blood-thinning medication, such as warfarin or aspirin.
Is the PTT Test Performed?
To perform the test, your doctor will need to take a sample of
blood from your arm. They’ll clean the site with an alcohol swab and insert a
needle into your vein. A tube attached to the needle will collect blood. After
collecting enough blood, they’ll remove the needle and cover the puncture site
with a gauze pad.
Your doctor will then add chemicals to this blood sample and
measure the number of seconds it takes for the sample to clot.
Do the Results Mean?
Normal PTT Test Results
PTT test results are measured in seconds. Normal results are
typically 25 to 35 seconds. This means that it took your blood sample 25 to 35
seconds to clot after adding the chemicals.
The exact standards for normal results may vary depending on your
doctor and lab, so ask your doctor if you have any concerns.
Abnormal PTT Test Results
Remember that an abnormal PTT result doesn’t diagnose any
particular disease. It only provides insight about the time it takes for your
blood to clot. Multiple diseases and conditions can cause abnormal PTT results.
A high PTT result may be due to:
- reproductive conditions, such as recent
pregnancy, current pregnancy, or recent miscarriage
- hemophilia A or B
- deficiency of blood clotting factors
- von Willebrand’s disease (a disorder that causes
abnormal blood clotting)
- disseminated intravascular coagulation (a
disease in which the proteins responsible for blood clotting are abnormally
- hypofibrinogenemia (deficiency of the blood
clotting factor fibrinogen)
- certain medications, such as the blood thinners
heparin and warfarin
- nutritional issues, such as vitamin K deficiency
- antibodies, including cardiolipin antibodies
- lupus anticoagulants
- liver disease
The wide range of possible causes for abnormal results means that
this test alone is not enough to determine what condition you have. An abnormal
result will probably prompt your doctor to order additional tests.