Is Goodpasture Syndrome?
Goodpasture syndrome is a rare and potentially life-threatening
autoimmune disease. It occurs when your immune system mistakenly attacks the
walls of your lungs and the tiny filtering units in your kidneys. The disorder
is named after Dr. Ernest Goodpasture, who identified the syndrome in 1919.
Without prompt diagnosis and treatment, the disease can lead to
bleeding in your lungs, kidney failure, and even death.
Are the Symptoms?
Symptoms may start out slowly, gradually affecting your lungs and
then your kidneys. In other cases they may progress rapidly, becoming severe in
a matter of days. Initial symptoms may include:
- fatigue, weakness, or lethargy
- nausea or vomiting
- loss of appetite
- unhealthy, pale appearance
If the disease moves to affect your lungs, the following symptoms
- dry cough
- coughing up blood (hemoptysis)
- shortness of breath or difficulty breathing
Sometimes symptoms affecting your lungs can become life threatening,
particularly if there is a lot of bleeding.
If the disease affects your kidneys, it may cause:
- burning sensation during urination
- blood in your urine or foamy urine
- swelling of your hands and feet
- elevated blood pressure readings
- back pain below your ribs
Causes Goodpasture Syndrome?
While the exact cause of Goodpasture syndrome is unknown, certain
behaviors and environmental factors are believed to put people at higher risk.
Certain respiratory infections may trigger the disease. Exposure to hydrocarbon
fumes, metallic dust, tobacco smoke, or certain illegal substances, such as
cocaine, may also increase risk.
Scientists believe the immune system attacks lung and kidney
tissue because the condition fools your body’s defenses into thinking those
parts are foreign to the body itself.
According to the National Kidney
Foundation (NKF), Goodpasture syndrome affects men more often than women
and occurs most commonly in early adulthood or after the age of 60. The NFK
also reports that the disease is more common in Caucasians than in other races.
Is Goodpasture Syndrome Diagnosed?
Your doctor may use several tests to diagnose Goodpasture
syndrome. Your doctor will start with a regular physical examination, checking
for high blood pressure, bleeding, and abnormal heart and lung sounds. Your
doctor will also review your medical history.
Other tests can help determine whether or not you have the
disease. A blood test may
show the presence of antibodies (proteins produced by your immune system to
fight whatever it is that has been identified as a threat) that indicate the
presence of the disease. It can also show a high level of waste products, which
may indicate kidney problems.
The presence of blood and protein in your urine can be detected
through urine testing.
These symptoms can also indicate kidney problems.
A chest X-ray may
show the presence of abnormal white patches that indicate bleeding in your
A kidney biopsy may
reveal changes that indicate the presence of Goodpasture syndrome. During this
test, a sample of tissue from your kidney is removed and sent to a lab for
testing. Lab technicians will look for the presence of antibodies or other
abnormal cells to help your doctor make a diagnosis.
Is Goodpasture Syndrome Treated?
Treatments involve medications that slow down your immune system.
These may include one or more of the following:
or cytoxic drugs keep your immune system from making the antibodies that
damage your lungs and kidneys (one example is cyclophosphamide)
such as prednisone,
help control bleeding in your lungs. These medications also suppress your
A treatment called plasmapheresis may
be used to help filter out harmful antibodies in your blood. During this
procedure, blood is withdrawn, and the liquid portion (plasma) is removed and
replaced. The "cleaned" blood is transferred back into your body.
Other treatments depend on your age, overall health, and the
severity of the disease. Your doctor may prescribe additional medications to
control fluid build-up and high blood pressure. In addition to medication,
dietary changes such as cutting down on salt intake can help control swelling
and blood pressure.
Is the Long-Term Outlook?
The more lung and kidney function can be preserved, the better.
The outlook seems particularly dependent on the condition of your kidneys.
Damage to the kidneys is often permanent, and a kidney transplant or dialysis
(a process that uses specialized machinery to help filter waste and toxins out
of the blood) may be necessary if your kidneys begin to fail.
An early diagnosis is very important to survive the disease and
for your long-term outlook. According to the NKF, the syndrome
can last anywhere from a few weeks to two years. The five-year survival rate is
Fewer than 30 percent of people
with Goodpasture syndrome will suffer long-term kidney damage that requires