Is the Epstein-Barr Virus Test?
The Epstein-Barr virus (EBV) is a member of the herpes virus
family. It’s one of the most common viruses to infect people around the world. According
to Boston Children’s Hospital, as many as 95
percent of adults between 35 and 40 years of age have been infected with
EBV at some point in their lives.
The virus typically causes no symptoms in children. In
adolescents and adults, it causes an illness called infectious mononucleosis,
or mono, in about 35
to 50 percent of the cases. Also known as “the kissing disease,” the virus
is usually spread through saliva. It’s very rare for the disease to be spread
through blood or other bodily fluids.
The EBV test is also known as “EBV antibodies.” It’s a blood test
used to identify an EBV infection. The test detects the presence of antibodies.
Antibodies are proteins that your body’s immune system releases in response to
a harmful substance called an antigen. Specifically, the EBV test is used to
detect antibodies to EBV antigens. The test can find both a current and past infection.
Will Your Doctor Order the Test?
Your doctor may order this test if you show any of the signs and
symptoms of mono. Symptoms typically last for one to four weeks, but they can
last up to three to four months in some cases. They include:
- sore throat
- swollen lymph nodes
- stiff neck
Your doctor may also take into account your age and other factors
when deciding whether or not to order the test. Mono is most common in teens
and young adults between the ages of 15 to 25.
Is the Test Performed?
The EBV test is a blood test. During the test, blood is drawn at
your doctor’s office, or at an outpatient clinical laboratory (or hospital lab).
Blood is drawn from a vein, usually on the inside of your elbow. The procedure
involves the following steps:
- The puncture site is cleaned with an antiseptic.
- An elastic band is wrapped around your upper arm
to make your vein swell with blood.
- A needle is gently inserted into your vein to
collect blood in an attached vial or tube.
- The elastic band is removed from your arm.
- The blood sample is sent to a lab for analysis.
Very little (or even zero) antibodies may be found early in the
illness. Therefore, the blood test may need to be repeated in 10 to 14 days.
Are the Risks of an EBV Test?
As with any blood test, there’s a slight risk of bleeding,
bruising, or infection at the puncture site. You may feel moderate pain or a
sharp prick when the needle is inserted. Some people feel light-headed or faint
after having their blood drawn.
Do Normal Results Mean?
A normal result means that no EBV antibodies were present in your
blood sample. This indicates that you have never been infected with EBV and don’t
have mono. However, you can still get it at any point in the future.
Do Abnormal Results Mean?
An abnormal result means that the test has detected EBV
antibodies. This indicates that you’re currently infected with EBV or have been
infected with the virus in the past. Your doctor can tell the difference
between a past and a current infection based on the presence or absence of
antibodies that fight three specific antigens.
The three antibodies the test looks for are viral capsid antigen
(VCA) IgG, VCA IgM, and Epstein-Barr nuclear antigen (EBNA).
- The presence of VCA IgG antibodies indicates
that an EBV infection has occurred at some time recently or in the past.
- The presence of VCA IgM antibodies and the
absence of antibodies to EBNA mean that the infection has occurred recently.
- The presence of antibodies to EBNA means that the
infection occurred sometime in the past. Antibodies to EBNA develop six to
eight weeks after the time of infection and are present for life.
As with any test, false-positive and false-negative results do happen.
A false-positive test result shows that you have a disease when you actually
don’t. A false-negative test result indicates that you don’t have a disease
when you really do. Ask your doctor about any follow-up procedures or steps that
can help make sure your test results are accurate.
Is EBV Treated?
There are no known treatments, antiviral drugs, or vaccines
available for mono. However, there are things you can do to ease your symptoms:
- Stay hydrated and drink a lot of fluids.
- Get plenty of rest.
- Take over-the-counter pain relievers, such as
Advil or Tylenol.
The virus can be hard to treat, but symptoms usually resolve on
their own in one to two months.
After you recover, EBV will remain dormant in your blood cells
for the rest of your life. This means that your symptoms will go away, but the
virus will stay in your body and can occasionally reactivate without causing symptoms.
It’s possible to spread the virus to others through mouth-to-mouth contact
during this time.