Disseminated Intravascular Coagulation (DIC)Disseminated intravascular coagulation (DIC) is a rare, life-threatening condition that prevents blood from clotting normally. The blood clot...
- Auto Immune Conditions
- Bladder & Kidney Health
- Brain & Nervous System
- Care Transitions
- Dental Health
- Emotional Health
- Eye Health
- Falls Prevention
- Financial Planning
- General Safety
- Health Care Basics
- Healthy Living
- Hearing Loss
- Heart Health
- High Blood Pressure
- Life Transitions
- Lung Health
- Men's Health
- Nutrition & Weight Management
- Pain Management
- Preventive Health
- Sexual Health
- Stomach & Digestive Health
- Stress & Anxiety
- Women's Health
Disseminated intravascular coagulation (DIC) is a rare, life-threatening condition that prevents blood from clotting normally. The blood clots reduce blood flow and can block blood from reaching bodily organs. This increased clotting can use up the blood’s platelets and clotting factors. Fewer platelets and clotting factors available result in excessive bleeding.
DIC is a serious condition that can lead to death. If you have bleeding that won’t stop, go to the emergency room, or call 911.
When the proteins used in your normal clotting process become overly active, it can cause DIC. Infection, severe trauma (i.e., brain injuries, crushing injuries) inflammation, surgery, and cancer are all known to contribute to this condition.
Some less common causes of DIC include the following:
- extremely low body temperature (hypothermia)
- venomous snake bites
- complications during pregnancy
You may also develop DIC if you go into shock.
Your risk for DIC is elevated if you have recently:
- undergone surgery
- delivered a baby
- had an incomplete miscarriage
- had a blood transfusion
- had anesthesia
- sepsis or any other fungal or bacterial blood infection
- certain types of cancer, especially some leukemias
- serious tissue damage such as a head injury, burns, or trauma
- liver disease
Bleeding, sometimes from multiple locations on the body, is one of the more common symptoms of DIC. Bleeding from the mucosa tissue (in the mouth and nose), and bleeding from other external areas may occur. In addition, DIC may also cause internal bleeding.
Other symptoms are:
- blood clots
- decreased blood pressure
- rectal or vaginal bleeding
- red dots on the surface of the skin
If you have cancer, DIC generally begins slowly, and clotting in the veins is more common than excessive bleeding.
DIC can cause complications, especially when it is not treated properly. The clots in the vessels will result in an inadequate oxygen supply reaching your organs. This has the potential to cause organ damage. Other complications include:
- lack of oxygen to limbs and organs
- excessive bleeding that may lead to death
DIC may be identified through various tests related to your levels of platelets, clotting factors and other blood components. However, there is not a standard procedure. The following are some tests that may be conducted if your doctor suspects DIC.
- fibrin degradation product
- complete blood cell count (CBC) from a blood smear
- complete blood cell count (CBC) from sample
- platelet count
- partial thromboplastin time
- D-dimer test
- serum fibrinogen
- prothrombin time
Treating the Cause
DIC treatment depends on what is causing the disorder. Treatment of the underlying condition is the main goal. To treat the clotting problem, you may be given an anticoagulant called heparin to reduce and prevent clotting. However, heparin may not be administered if you have a severe lack of platelets or are bleeding too excessively.
People with acute DIC require hospitalization, often in an intensive care unit (ICU), where treatment will attempt to correct the problem causing the DIC while maintaining the function of the organs.
A transfusion may be needed to replace the platelets that you are missing. Plasma transfusions have the ability to replace the clotting factors that you are lacking.
Your prognosis relates to what is causing DIC. If the initial problem can be corrected, then DIC will resolve. If not, DIC can be life threatening.
Edited by: Eric Searleman
Medically Reviewed by: Sylvia S. Hanna, MD
Published: Jul 25, 2012
Last Updated: Oct 8, 2013
Published By: Healthline Networks, Inc.
- Disseminated Intravascular Coagulation (DIC). (n.d.). The Merck Manuals. Retrieved March 18, 2012, from http://www.merckmanuals.com/home/blood_disorders/bleeding_and_clotting_disorders/disseminated_intravascular_coagulation_dic.html
- Disseminated intravascular coagulation (DIC). (n.d.). MedlinePlus Medical Encyclopedia. Retrieved March 18, 2012, from http://www.nlm.nih.gov/medlineplus/ency/article/000573.htm
- Disseminated intravascular coagulation (DIC). (n.d.). PubMed Health. Retrieved March 18, 2012, from http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001599/
- What Is Disseminated Intravascular Coagulation?. (n.d.). NIH Heart, Lung and Blood Institute. Retrieved March 18, 2012, from http://www.nhlbi.nih.gov/health/health-topics/topics/dic/