What Is Acute Myeloid Leukemia?
Acute myeloid leukemia (AML) is a cancer that occurs in your
blood and in the marrow of your bones. Marrow is a sponge-like material inside your
bones that produces blood cells. AML specifically affects the white blood cells
of your body, causing them to form abnormally. The number of abnormal cells
There are about 20,830
new cases of AML every year in the United States.
What Are the Symptoms of AML?
In its early stages, the symptoms of AML may resemble the flu and
you may have a fever and fatigue. Other symptoms can include:
- bone pain
- frequent nosebleeds
- bleeding and swollen gums
- easy bruising
- excessive sweating (particularly at night)
- shortness of breath
- unexplained weight loss
- heavier than normal periods in women
What Causes AML?
AML is caused by abnormalities in the DNA that controls the
development of cells in your bone marrow. If you have AML, your bone marrow
creates countless white blood cells that are immature. These abnormal cells
eventually become leukemic white blood cells called myeloblasts. These abnormal
cells build up and replace healthy cells. This causes your bone marrow to stop
functioning properly, making your body more susceptible to infections.
It’s not clear exactly what causes the DNA mutation. Some doctors
believe it may be related to exposure to certain chemicals, radiation, and even
drugs used for chemotherapy.
What Raises Your Risk of AML?
Your risk of developing AML increases with age. The average age
for a person with AML is about 67.
AML is also more common in men than women.
Cigarette smoking is thought to increase your risk of developing
AML. If you work in an industry where you may have been exposed to chemicals such
as benzene, you’re also at higher risk. Your risk also goes up if you have a
blood disorder such as myelodysplasia or a genetic disorder such as Down
These risk factors don’t mean you’ll necessarily develop AML. At
the same time, it’s possible for you to develop AML without having any of these
How Is AML Diagnosed?
Your doctor will perform a physical exam and check for swelling
of your liver, lymph nodes, and spleen. Your doctor may also order blood tests
to check for anemia and to determine your white blood cell levels.
While a blood test may help your doctor determine whether there’s
a problem, a bone marrow test or biopsy is needed to diagnose AML definitively.
A sample of bone marrow is taken by inserting a long needle into your hip bone.
Although, sometimes the breastbone is the site of biopsy. The sample is sent to
a lab for testing.
Your doctor may also do a spinal tap, or lumbar puncture, which
involves withdrawing fluid from your spine with a small needle. The fluid is
checked for the presence of leukemia cells.
Treatment Options for AML
Treatment for AML involves two phases:
Remission Induction Therapy
therapy uses chemotherapy to kill the existing leukemia
cells in your body. Most people stay in the hospital during treatment because
chemotherapy also kills healthy cells, raising your risk for infection and
abnormal bleeding. In a rare form of AML called promyelocytic leukemia,
anti-cancer drugs such as arsenic trioxide or all-trans retinoic acid may be
used to target specific mutations in leukemia cells. These drugs kill the
leukemia cells and stop the unhealthy cells from dividing.
which is also known as post-remission therapy, is crucial for
keeping AML in remission and preventing a relapse. The goal of consolidation
therapy is to destroy any remaining leukemia cells. You may require a stem cell
transplant for consolidation therapy. Stem cells are often used to help your
body generate new and healthy bone marrow cells. The stem cells may come from a
donor. If you’ve previously had leukemia that has gone into remission, your
doctor may have removed and stored some of your own stem cells for a future
transplant, known as an autologous stem cell transplant.
Getting stem cells from a donor has more risks than getting a
transplant made up of your own stem cells. A transplant of your own stem cells,
however, involves a higher risk for relapse because some old leukemia cells may
be present in the sample retrieved from your body.
What Is Expected in the Long Term?
With early-phase detection and prompt treatment, remission is
highly likely in most people. Once all signs and symptoms of AML have
disappeared, you’re considered to be in remission. If you’re in remission for
more than five years, you’re considered cured of AML.
If you find that you have symptoms of AML, schedule an
appointment with your doctor to discuss them. You should also seek immediate
medical attention if you have any signs of infection or a persistent fever.
How Do You Prevent AML?
you work around hazardous chemicals or radiation, make sure to wear any and all
available protective gear to limit your exposure.