thioridazine (generic name)

Mellaril (brand name)

It is used to treat schizophrenia
(thye oh RID a zeen)
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What is this medicine?

THIORIDAZINE (thye oh RID a zeen) is used to treat schizophrenia. This medicine should only be used when other medications have not worked, because it can cause serious heart-related side effects.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • blood disorders
  • dementia
  • frequently drink alcoholic beverages
  • heart or liver disease
  • Parkinson's disease
  • uncontrollable movement disorder
  • an unusual or allergic reaction to thioridazine, other medicines foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth. Follow the directions on the prescription label. Shake well before using. Use a specially marked dropper to measure your medicine. Ask your pharmacist if you do not have one. Household spoons are not accurate. Mix the oral concentrate with half a glass (4 fluid ounces) of water, orange, or grapefruit juice. Do not mix with any drink containing caffeine (coffee, cola), tea, or apple juice. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. While this drug may be prescribed for children for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • amoxapine
  • arsenic trioxide
  • certain antibiotics like clarithromycin, erythromycin, gatifloxacin, grepafloxacin, moxifloxacin, sparfloxacin
  • cisapride
  • clozapine
  • diltiazem
  • droperidol
  • ephedrine
  • gefitinib
  • imatinib
  • levomethadyl
  • local anesthetics
  • medicines for mental depression
  • medicines to control irregular heart rhythms
  • octreotide
  • pentamidine
  • phenylpropanolamine
  • pimozide
  • pindolol
  • propranolol
  • ranolazine
  • risperidone
  • terbinafine
  • trimethobenzamide
  • ziprasidone

This medicine may also interact with the following medications:

  • barbiturate medicines like phenobarbital
  • diuretics
  • local and general anesthetics
  • phenytoin
  • prescription pain medicines
  • warfarin

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress.

You may get drowsy, dizzy, or have blurred vision. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can increase possible dizziness or drowsiness. Avoid alcoholic drinks.

This medicine can reduce the response of your body to heat or cold. Dress warm in cold weather and stay hydrated in hot weather. If possible, avoid extreme temperatures like saunas, hot tubs, very hot or cold showers, or activities that can cause dehydration such as vigorous exercise.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

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Last Updated: May 07, 2013
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