tacrolimus (generic name)

It is used to prevent organ rejection after a transplant.
(ta KROE li mus)
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What is this medicine?

TACROLIMUS (ta KROE li mus) is used to prevent organ rejection after a transplant.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • diabetes
  • heart disease or heart failure
  • high blood pressure
  • infection
  • kidney disease
  • an unusual or allergic reaction to tacrolimus, castor oil, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for infusion into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • astemizole
  • cidofovir
  • cisapride
  • cyclosporine
  • droperidol
  • grepafloxacin
  • pimozide
  • probucol
  • ziprasidone

This medicine may also interact with the following medications:

  • alcohol and medicines that contain alcohol
  • aminoglycosides
  • amphotericin B
  • antacids
  • bromocriptine
  • calcium channel blockers like diltiazem, nicardipine, nifedipine, and verapamil
  • carbamazepine
  • caspofungin
  • chloramphenicol
  • cimetidine
  • cisplatin
  • clarithromycin
  • danazol
  • diuretics
  • erythromycin
  • ethinyl estradiol
  • ganciclovir
  • medicines for fungal infections like clotrimazole, fluconazole, itraconazole, ketoconazole, and voriconazole
  • metoclopramide
  • omeprazole
  • phenobarbital
  • phenytoin
  • protease inhibitors
  • rifabutin
  • rifampin
  • sirolimus
  • St. John's wort
  • steroid medicines like prednisone or cortisone
  • troleandomycin
  • vaccines

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Your blood sugar may increase while you are taking this medicine. Call your doctor or health care professional for advice if you have any of the following symptoms: increased thirst, dry mouth, pass urine frequently, notice a fruity odor on your breath, or feel tired and lose your appetite.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • burning or tingling in the hands or feet
  • changes in vision
  • chest pain
  • fever, chills or any other sign of infection
  • increased thirst or hunger
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • seizures
  • swelling of the feet or legs, unusual or sudden weight gain
  • trouble passing urine or change in the amount of urine
  • unusual bleeding or bruising
  • unusually weak or tired
  • yellowing of skin or eyes

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • confusion
  • constipation
  • diarrhea
  • difficulty sleeping
  • headache
  • nausea
  • tremors

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Last Updated: February 27, 2009
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