ruxolitinib (generic name)

Jakafi (brand name)

It is used to treat myelofibrosis.
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What is this medicine?

RUXOLITINIB is used to treat myelofibrosis.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • immune system problems
  • infection (especially a virus infection such as chickenpox, cold sores, or herpes)
  • kidney disease
  • liver disease
  • low blood counts, like low white cell, platelet, or red cell counts
  • an unusual or allergic reaction to ruxolitinib, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

  • antiviral medicines for HIV or AIDS like delavirdine, indinavir, lopinavir; ritonavir, nelfinavir, ritonavir, saquinavir, tipranavir
  • antiviral medicines for Hepatitis C like boceprevir, telaprevir
  • certain antibiotics like clarithromycin, dalfopristin; quinupristin, erythromycin, isoniazid, telithromycin, rifampin
  • certain medicines for fungal infection like itraconazole, ketoconazole, posaconazole, voriconazole
  • conivaptan
  • grapefruit juice
  • mibefradil
  • nefazodone

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

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Last Updated: November 28, 2011
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