rifapentine (generic name)

It is used to treat of tuberculosis (TB)
(RIF a pen teen)
Table of Contents
powered by healthline

Average Ratings

What is this medicine?

RIFAPENTINE (RIF a pen teen) is an antibiotic. It is used to treat of tuberculosis (TB). This medicine is never used alone for tuberculosis, but in combination with at least one other agent.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • immune system problems
  • liver disease
  • an unusual or allergic reaction to rifapentine, rifabutin, rifampin, other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. If this medicine upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take your medicine more often than directed. For your therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the TB resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years old for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • medicines for HIV
  • voriconazole

This medicine may also interact with the following medications:

  • antifungal medicines like fluconazole, itraconazole, ketoconazole
  • barbituates, like phenobarbital
  • birth control pills
  • clofibrate
  • cyclosporine
  • levothyroxine
  • medicines that treat or prevent blood clots like warfarin
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for sleep
  • oral medicines for diabetes
  • quinine
  • sildenafil
  • some antibiotics like chloramphenicol, clarithromycin, dapsone, doxycycline, ciprofloxacin
  • some medicines for heart rhythm problems like disopyramide, mexiletine, quinidine, tocainide
  • some heart medicines like digoxin, diltiazem, nifedipine, verapamil
  • some medicines for seizures like phenytoin
  • some prescription pain medications like methadone
  • steroid medicines like prednisone or cortisone
  • tacrolimus
  • theophylline

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. You will need to have blood work done regularly while you are taking this medicine. This medicine can cause serious liver problems. Make sure you understand the risks for liver problems and how to identify the symptoms. If you have any questions, talk with your doctor or other health care provider.

Avoid alcoholic drinks while you are taking this medicine. Drinking alcohol during treatment with this medicine increases the risk of serious liver problems.

Do not treat diarrhea with over the counter products. Contact your doctor if you have diarrhea that lasts more than 2 days or if it is severe and watery.

You may need to take a vitamin B6 supplement while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your health care professional.

Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control.

Antacids may reduce the absorption of this medicine. Doses of this medicine should be given at least 1 hour before taking antacids.

This medicine can color your urine, feces (stool), perspiration (sweat), tears, sputum, skin or saliva reddish-orange to reddish-brown. This color can last for as long as you take this medicine and is not a cause for alarm. This color in tears may permanently stain soft contact lenses. It is better not to wear soft contact lenses while you are taking this medicine. This medicine may stain dentures.

Page: 1 2 Next >
Last Updated: July 28, 2009
Licensed from
Top of page
General Drug Tools
General Drug Tools view all tools
Tools for
Healthy Living
Tools for Healthy Living view all tools
Search Tools
Search Tools view all tools
Insurance Plan Tools
Insurance Plan Tools view all tools

What is a reference number?

When you register on this site, you are assigned a reference number. This number contains your profile information and helps UnitedHealthcare identify you when you come back to the site.

If you searched for a plan on this site in a previous session, you might already have a reference number. This number will contain any information you saved about plans and prescription drugs. To use that reference number, click on the "Change or view saved information" link below.

You can retrieve information from previous visits to this site, such as saved drug lists and Plan Selector information.