rifampin (generic name)

Rimactane (brand name)

It is used to treat or prevent certain kinds of bacterial infections
(RIF am pin)
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What is this medicine?

RIFAMPIN (RIF am pin) is an antibiotic. It is used to treat or prevent certain kinds of bacterial infections. It is used to treat or prevent tuberculosis (TB). It will not work for colds, flu, or other viral infections.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • liver disease, including hepatitis
  • an unusual or allergic reaction to rifampin, rifabutin, other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine on an empty stomach, either 1 hour before or 2 hours after food. Take your doses at regular intervals. Do not take your medicine more often than directed. For your therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the TB resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • delavirdine
  • nevirapine
  • sirolimus
  • voriconazole

This medicine may also interact with the following medications:

  • antibiotics like ciprofloxacin, clarithromycin, isoniazid
  • antifungal medicines like fluconazole, itraconazole, ketoconazole
  • atovaquone
  • chloramphenicol
  • cyclosporine
  • dapsone
  • female hormones, including contraceptive or birth control pills
  • halothane
  • medicines for blood pressure, other heart problems
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for diabetes
  • medicines for pain
  • medicnes for seizures like carbamazepine, phenobarbital, phenytoin
  • medicines for sleep
  • medicines for the thyroid
  • medicines that treat or prevent blood clots like warfarin
  • probenecid
  • steroid medicines like prednisone or cortisone
  • vitamin D

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. This medicine can cause serious liver problems. Make sure you understand the risks for liver problems and how to identify the symptoms. If you have any questions, talk with your doctor or other health care provider.

Avoid alcoholic drinks while you are taking this medicine. Drinking alcohol during treatment with this medicine increases the risk of serious liver problems.

Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control.

Antacids may reduce the absorption of this medicine. Doses of this medicine should be given at least 1 hour before taking antacids.

This medicine can color your urine, feces (stool), perspiration (sweat), tears, sputum, skin or saliva reddish-orange to reddish-brown. This color can last for as long as you take this medicine and is not a cause for alarm. This color in tears may permanently stain soft contact lenses. It is better not to wear soft contact lenses while you are taking this medicine.

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Last Updated: July 28, 2009
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