rifabutin (generic name)

Mycobutin (brand name)

It is used to prevent mycobacterium avium complex (MAC) in people with HIV infection
(RIF a byoo tin)
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What is this medicine?

RIFABUTIN (RIF a byoo tin) is an antibiotic. It is used to prevent mycobacterium avium complex (MAC) in people with HIV infection. This medicine does not cure or prevent HIV. It will not work for colds, flu, or other viral infections.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • kidney disease
  • tuberculosis
  • wear contact lenses
  • an unusual or allergic reaction to rifabutin, rifampin, rifapentine, rifaximin, other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take your medicine more often than directed. It is important to take all of your medicine as directed even if you think your are better. Do not skip doses or stop your medicine early.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. Tell your health care professional about all missed doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • clarithromycin
  • delavirdine
  • erythromycin
  • sirolimus
  • troleandomycin
  • voriconazole

This medicine may also interact with the following medications:

  • dapsone
  • female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections
  • fluconazole
  • itraconazole
  • medicines that treat or prevent blood clots like warfarin
  • medicines for HIV
  • sulfamethoxazole; trimethoprim

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular check ups.

This medicine can color your urine, stool, sweat, tears, sputum, skin or saliva red, orange or brown. This is not a cause for alarm. However, soft contact lenses may be permanently stained.

Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives
  • breathing problems
  • changes in vision
  • chest pain
  • dark urine
  • fever or chills, sore throat
  • general ill feeling or flu-like symptoms
  • light-colored stools
  • loss of appetite, nausea
  • right upper belly pain
  • unusual bleeding or bruising
  • unusually weak or tired
  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea
  • headache
  • loss of appetite
  • muscle aches, pains
  • nausea, vomiting
  • orange to brown color of urine, stools, saliva, tears, soft contact lenses, and sweat
  • stomach pain, upset
  • unusual taste

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Last Updated: July 28, 2009
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