repaglinide (generic name)

Prandin (brand name)

It helps to control blood sugar
(re PAG lin ide)
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What is this medicine?

REPAGLINIDE (re PAG lin ide) helps to treat type 2 diabetes. It helps to control blood sugar. Treatment is combined with diet and exercise.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • diabetic ketoacidosis
  • kidney disease
  • liver disease
  • severe infection or injury
  • an unusual or allergic reaction to repaglinide or other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. The dose should be taken no earlier than 30 minutes before every meal. If an extra meal is added, take a tablet before that meal. If a meal is skipped, skip the dose for that meal. Do not take more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Elderly patients over 65 years old may have a stronger reaction and need a smaller dose.

What if I miss a dose?

If you miss a dose before a meal, skip that dose. If it is almost time for your next dose, take only that dose with the next scheduled meal as directed. Do not take double or extra doses.

What may interact with this medicine?

  • barbiturates like phenobarbital or primidone
  • carbamazepine
  • clarithromycin
  • erythromycin
  • gemfibrozil
  • isophane insulin, NPH
  • medicines for fungal or yeast infections such as itraconazole, ketoconazole, miconazole
  • montelukast
  • other medicines for diabetes
  • rifampin
  • simvastatin

Many medications may cause an increase or decrease in blood sugar, these include:

  • alcohol containing beverages
  • aspirin and aspirin-like drugs
  • chloramphenicol
  • chromium
  • diuretics
  • female hormones, such as estrogens or progestins, birth control pills
  • heart medicines
  • isoniazid
  • male hormones or anabolic steroids
  • medications for weight loss
  • medicines for allergies, asthma, cold, or cough
  • medicines for mental problems
  • medicines called MAO inhibitors - Nardil, Parnate, Marplan, Eldepryl
  • niacin
  • NSAIDS, such as ibuprofen
  • pentamidine
  • phenytoin
  • probenecid
  • quinolone antibiotics such as ciprofloxacin, levofloxacin, ofloxacin
  • some herbal dietary supplements
  • steroid medicines such as prednisone or cortisone
  • thyroid hormones

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress.

Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.

If you have low blood sugar, eat or drink something that has sugar. Make sure others know to get medical help quickly if you have serious symptoms of low blood sugar, like if you become unconscious or have a seizure.

If you need surgery, tell your doctor or health care professional that you are taking this medicine.

Wear a medical identification bracelet or chain to say you have diabetes, and carry a card that lists all your medications.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • breathing difficulties
  • dark yellow or brown urine, or yellowing of the eyes or skin
  • fever, chills, sore throat
  • low blood sugar (ask your doctor or healthcare professional for a list of these symptoms)
  • severe skin rash, redness, swelling, or itching
  • unusual bleeding or bruising
  • vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea
  • headache
  • muscle pain
  • nausea

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Last Updated: August 17, 2009
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