pyrazinamide (generic name)

It is used for the prevention or treatment of tuberculosis (TB) infections
(peer a ZIN a mide)
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What is this medicine?

PYRAZINAMIDE (peer a ZIN a mide) is used for the prevention or treatment of tuberculosis (TB) infections. This medicine is usually used in combination with at least one other agent.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • gout
  • if you frequently drink alcohol containing drinks
  • liver disease
  • an unusual or allergic reaction to pyrazinamide, other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed. For your therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the TB resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

  • alcohol

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular check ups. You will need blood work done regularly.

Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

You may get a false-positive result for sugar in your urine while you are taking this medicine. Talk with your doctor.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • dark urine
  • fever
  • general ill feeling or flu-like symptoms
  • gout pain, joint swelling or pain
  • light-colored stools
  • loss of appetite, nausea
  • right upper belly pain
  • trouble passing urine or change in the amount of urine
  • unusual bleeding or bruising
  • unusually weak or tired
  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • aches and pains
  • acne
  • sensitivity to sun or ultraviolet light
  • stomach pain

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Last Updated: July 16, 2009
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