promethazine injection (generic name)

Promacot (brand name)

It is used to treat allergic reactions and to treat or prevent nausea and vomiting from illness or motion sickness
(proe METH a zeen)
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What is this medicine?

PROMETHAZINE (proe METH a zeen) is an antihistamine. It is used to treat allergic reactions and to treat or prevent nausea and vomiting from illness or motion sickness. It is also used to make you sleep before surgery, and to help treat pain or nausea after surgery.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • glaucoma
  • high blood pressure or heart disease
  • kidney disease
  • liver disease
  • lung or breathing disease, like asthma
  • prostate trouble
  • pain or difficulty passing urine
  • seizures
  • an unusual or allergic reaction to promethazine or phenothiazines, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection into a muscle, or into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. This medicine should not be given to infants and children younger than 2 years old.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • medicines called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl
  • other phenothiazines like trimethobenzamide

This medicine may also interact with the following medications:

  • barbiturates like phenobarbital
  • bromocriptine
  • certain antidepressants
  • certain antihistamines used in allergy or cold medicines
  • epinephrine
  • levodopa
  • medicines for sleep
  • medicines for mental problems and psychotic disturbances
  • medicines for movement abnormalities as in Parkinson's disease, or for gastrointestinal problems
  • muscle relaxants
  • prescription pain medicines

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.

Your healthcare professional will discuss with you the risks and the benefits of using this medicine. This medicine has caused serious side effects in some patients after it was injected into a vein. Watch closely for any signs or symptoms of a local reaction like burning, pain, redness, swelling, and blistering and tell your healthcare professional immediately if any occur. These symptoms may occur when you receive the injection or may occur hours or even days after the injection.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. To reduce the risk of dizzy or fainting spells, do not stand or sit up quickly, especially if you are an older patient. Alcohol may increase dizziness and drowsiness. Avoid alcoholic drinks.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water will help.

This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go away or is severe.

Keep out of the sun, or wear protective clothing outdoors and use a sunscreen. Do not use sun lamps or sun tanning beds or booths.

If you are diabetic, check your blood-sugar levels regularly.

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Last Updated: September 16, 2009
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