progesterone vaginal (generic name)

Crinone (brand name)

This medicine is used to treat infertility and to prevent miscarriage in women with a condition called corpus luteum insufficiency
(proe JES ter one)
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What is this medicine?

PROGESTERONE (proe JES ter one) is a female hormone. This medicine is used to treat infertility and to prevent miscarriage in women with a condition called corpus luteum insufficiency. This medicine may also be used to prevent preterm delivery in some women. The suppositories are only available when compounded by your pharmacist.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • blood vessel disease, blood clotting disorder, or suffered a stroke
  • breast, cervical or vaginal cancer
  • heart disease
  • kidney disease
  • liver disease
  • miscarriage or abortion
  • vaginal bleeding
  • an unusual or allergic reaction to progesterone, other hormones, medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for vaginal use only. Do not take by mouth. Follow the directions on the prescription label. Wash your hands before and after use. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medicine?

Interactions are not expected. Do not use any other vaginal products without asking your doctor or health care professional.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress.

If your doctor or health care professional instructs you to use any other medicines in the vagina while you are using this medicine, you should separate the doses by at least 6 hours.

You may notice a white discharge of medicine while using this medicine. This is normal. If it becomes bothersome, contact your doctor or health care professional.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • abnormal vaginal bleeding
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breast tissue changes or discharge
  • changes in vision
  • chest pain
  • confusion
  • dark urine
  • general ill feeling or flu-like symptoms
  • light-colored stools
  • loss of appetite, nausea
  • pain, swelling, warmth in the leg
  • right upper belly pain
  • problems with balance, talking, walking
  • severe headaches
  • shortness of breath
  • sudden numbness or weakness of the face, arm or leg
  • unusually weak or tired
  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • back pain
  • depressed mood or mood swings
  • increased appetite
  • fluid retention and swelling
  • nausea, vomiting
  • stomach cramps or bloating

Where should I keep my medicine?

Keep out of the reach of children.

Store in the refrigerator between 2 and 8 degrees C (36 and 46 degrees F). Do not freeze. Protect from light. Keep this medicine in the orginal container until ready to use. Throw away any unused medicine after the expiration date.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Last Updated: July 20, 2009
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