pimozide (generic name)

It helps to reduce the muscle and speech tics that are caused by Tourette's syndrome.
(PI moe zide)
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What is this medicine?

PIMOZIDE (PI moe zide) helps to reduce the muscle and speech tics that are caused by Tourette's syndrome.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • dementia
  • heart disease
  • kidney disease
  • liver disease
  • Parkinson's disease
  • an unusual or allergic reaction to pimozide, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. While this medicine may be prescribed for children as young as 12 years of age for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • aprepitant
  • arsenic trioxide
  • certain macrolide antibiotics like clarithromycin, dirithromycin, erythromycin
  • chloroquine
  • cimetidine
  • cisapride
  • clozapine
  • conivaptan
  • cyclobenzaprine
  • dalfopristin; quinupristin
  • diltiazem
  • droperidol
  • grapefruit juice
  • haloperidol
  • halothane
  • imatinib
  • isoniazid
  • levomethadyl
  • local anesthetics
  • maprotiline
  • medicines for fungal infections like ketoconazole, itraconazole, posaconazole, and voriconazole
  • medicines used to treat ADHD like amphetamine, dexmethylphenidate, dextroamphetamine, methylphenidate
  • methadone
  • mifepristone
  • nicardipine
  • pemoline
  • pentamidine
  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
  • quinine
  • ranolazine
  • sodium phosphates
  • some medicines for HIV
  • some medicines for treating heart-rhythm problems
  • some medicines for treating depression or other mental illness such as citalopram, escitalopram, paroxetine, sertraline, fluvoxamine, and nefazodone
  • some quinolone antibiotics
  • tacrolimus
  • telithromycin
  • vardenafil
  • verapamil
  • zafirlukast
  • zileuton
  • ziprasidone

This medicine may also interact with the following medications:

  • barbiturates, like phenobarbital
  • bosentan
  • carbamazepine
  • ciprofloxacin
  • enoxacin
  • isoniazid (INH)
  • levodopa
  • medicines for sleep or anxiety
  • medicines for treating seizures
  • norfloxacin
  • pain relievers
  • rifampin
  • some medicines for treating asthma
  • some medicines for treating pain
  • tacrine

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. It may be several weeks before you see the full effects of this medicine. Do not stop taking this medicine suddenly. You may need to gradually reduce the dose. Only stop taking this medicine on advice of your doctor or health care professional.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can increase dizziness and drowsiness. Avoid alcoholic drinks.

Do not drink grapefruit juice products while taking this medicine. This can increase the chance of developing serious heart problems.

This medicine can reduce the response of your body to heat or cold. Dress warm in cold weather and stay hydrated in hot weather. If possible, avoid extreme temperatures like saunas, hot tubs, very hot or cold showers, or activities that can cause dehydration such as vigorous exercise.

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Last Updated: May 07, 2013
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