phenylephrine-promethazine (generic name)

It is used to treat the symptoms of allergy and colds
(fen il EF rin; proe METH a zeen)
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What is this medicine?

PHENYLEPHRINE; PROMETHAZINE (fen il EF rin; proe METH a zeen) is a decongestant and a antihistamine. It is used to treat the symptoms of allergy and colds. This medicine will not treat an infection.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of the following conditions:
  • diabetes
  • enlarged prostate
  • glaucoma
  • heart disease
  • liver disease
  • seizure disorder
  • serious illness
  • sleep apnea
  • thyroid disease
  • trouble passing urine
  • ulcer or other stomach problem
  • an unusual or allergic reaction to phenylephrine, promethazine, phenothiazines, sulfites, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Use a specially marked spoon or container to measure your medicine. Household spoons are not accurate. Take your doses at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 2 years of age for selected conditions, precautions do apply. Do not use in children under 2 years old.

Patients over 65 years old may have a stronger reaction and need a smaller dose.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • bromocriptine
  • cocaine
  • disopyramide
  • ergotamine, dihydroergotamine
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • procarbazine
  • risperidone
  • stimulant drugs

This medicine may also interact with the following medications:

  • alcohol
  • barbiturate medicines like phenobarbital
  • cabergoline
  • caffeine
  • diet aids
  • epinephrine
  • heart medicines
  • linezolid
  • medicines for asthma
  • medicines for cold or allergies
  • medicines for depression, anxiety or psychotic disturbances
  • medicines for Parkinson's disease
  • medicines for sleep
  • medicines for the stomach like metoclopramide, dicyclomine, glycopyrrolate
  • oxytocin
  • pain medicines
  • radio contrast dyes
  • St. John's wort
  • theophylline

What should I watch for while using this medicine?

Tell your doctor if your symptoms do not improve or if they get worse.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go away or is severe.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

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Last Updated: July 16, 2009
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