paliperidone (generic name)

It is used to treat schizophrenia and schizoaffective disorder.
(pal ee PER i done)
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What is this medicine?

PALIPERIDONE (pal ee PER i done) is used to treat schizophrenia and schizoaffective disorder.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • chronic constipation or diarrhea
  • dementia
  • diabetes or family history of diabetes
  • history of stroke
  • irregular heartbeat or low blood pressure
  • kidney disease
  • liver disease
  • stomach problems like adhesions, bowel disease, short gut, trouble swallowing
  • an unusual or allergic reaction to paliperidone, risperidone, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not chew, crush, or cut the tablets. You can take this medicine with or without food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your prescriber's advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years old for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • bepridil
  • cisapride
  • droperidol
  • grepafloxacin
  • halofantrine
  • levomethadyl
  • pimozide
  • sertindole
  • some phenothiazines like chlorpromazine, mesoridazine, thioridazine
  • sparfloxacin

This medicine may also interact with the following medications:

  • abarelix
  • alcohol
  • alfuzosin
  • antibiotics like clarithromycin, erythromycin, gemifloxacin, levofloxacin
  • carbamazepine
  • chloroquine
  • cyclobenzaprine
  • daunorubicin, doxorubicin
  • dolasetron
  • levodopa and other medications for Parkinson's disease
  • lithium
  • local anesthetics
  • medicines for anxiety, depression or psychotic disturbances
  • medicines for blood pressure
  • medicines for irregular heartbeat
  • medicines for sleep
  • medicines for treating seizures
  • octreotide
  • ondansetron
  • other medicines for schizophrenia
  • pentamidine
  • prescription pain medications
  • rifampin
  • St. John's Wort
  • tramadol
  • vorinostat

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. It may be several weeks before you see the full effects. Do not suddenly stop taking this medicine. You may need to gradually reduce the dose. Only stop taking this medicine on the advice of your doctor or health care professional.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This medicine can reduce the response of your body to heat or cold. Dress warm in cold weather and stay hydrated in hot weather. If possible, avoid extreme temperatures like saunas, hot tubs, very hot or cold showers, or activities that can cause dehydration such as vigorous exercise.

The tablet shell for some brands of this medicine does not dissolve. This is normal. The tablet shell may appear whole in the stool. This is not a cause for concern.

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Last Updated: May 07, 2013
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