lansoprazole-naproxen (generic name)

The naproxen is a non-steroidal anti-inflammatory drug (NSAID)
(na PROX en; lan SOE pra zole)
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What is this medicine?

NAPROXEN; LANSOPRAZOLE (na PROX en; lan SOE pra zole) is a combination of two medicines. The naproxen is a non-steroidal anti-inflammatory drug (NSAID). It is used to reduce swelling and to treat pain. This medicine may be used for painful joint problems such as arthritis. The lansoprazole is a proton pump inhibitor (PPI) that is used to prevent stomach ulcers that may be caused by the naproxen.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • asthma
  • cigarette smoker
  • drink more than 3 alcohol containing beverages a day
  • heart disease or circulation problems such as heart failure or leg edema (fluid retention)
  • high blood pressure
  • kidney disease
  • liver disease
  • low levels of magnesium in the blood
  • stomach bleeding or ulcers
  • an unusual or allergic reaction to naproxen, aspirin, other NSAIDs, lansoprazole or other proton pump inhibitors, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not crush or chew. Take your medicine at regular intervals. Do not take it more often than directed. Long term, continuous use may increase the risk of heart attack or stroke.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • atazanavir
  • nelfinavir

This medicine may also interact with the following medications:

  • alcohol
  • ampicillin
  • antacids
  • aspirin and aspirin-like medicines
  • cidofovir
  • delavirdine
  • digoxin
  • diuretics
  • iron salts
  • lithium
  • medicines for fungal infections like ketoconazole and itraconazole
  • medicines for stomach, or intestine problems, like acid reflux or GERD
  • medicines that treat or prevent blood clots like warfarin
  • methotrexate
  • pemetrexed
  • probenecid
  • steroid medicines like prednisone or cortisone
  • sucralfate
  • theophylline

What should I watch for while using this medicine?

Tell your doctor or health care professional if your pain does not get better. Talk to your doctor before taking another medicine for pain. Do not treat yourself.

You may need blood work done while you are taking this medicine.

This medicine does not prevent heart attack or stroke. In fact, this medicine may increase the chance of a heart attack or stroke. The chance may increase with longer use of this medicine and in people who have heart disease. If you take aspirin to prevent heart attack or stroke, talk with your doctor or health care professional.

Do not take other medicines that contain aspirin, ibuprofen, or naproxen with this medicine. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many medicines available without a prescription should not be taken with this medicine.

This medicine can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Do not smoke cigarettes or drink alcohol. These increase irritation to your stomach and can make it more susceptible to damage from this medicine. Ulcers and bleeding can happen without warning symptoms and can cause death.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

This medicine can cause you to bleed more easily. Try to avoid damage to your teeth and gums when you brush or floss your teeth.

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Last Updated: March 08, 2011
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