morphine-naltrexone (generic name)

Embeda (brand name)

It is used to treat moderate to severe pain that lasts for more than a few days
(MOR feen; nal TREX one)
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What is this medicine?

MORPHINE; NALTREXONE (MOR feen; nal TREX one) is a pain reliever. It is used to treat moderate to severe pain that lasts for more than a few days.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • adrenal gland problems, Addison's disease
  • brain tumor
  • constipation or other intestinal disease
  • drug abuse or addiction
  • head injury
  • heart disease
  • if you frequently drink alcohol-containing drinks
  • kidney disease or problems urinating
  • kyphoscoliosis
  • liver disease
  • lung disease, asthma, or breathing problems
  • problems with gallbladder or pancreas
  • seizures
  • thyroid problems
  • an unusual or allergic reaction to morphine, naltrexone, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. If the medicine upsets your stomach, take the medicine with food or milk. Swallow this medicine whole. Or, if you have problems swallowing the capsule, you may carefully open it and sprinkle the contents on a small amount of cold applesauce. Immediately swallow all of the applesauce. Do not save it for later. Do not chew the applesauce. Do not let the medicine dissolve in the applesauce. After you take the medicine, rinse your mouth with water. None of the medicine should stay in your mouth. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

This medicine can be very dangerous if you take it wrong. Do not dissolve, crush, or chew the capsules or the pellets inside the capsule. If you crush or break the pellets you may get too much medicine.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. This medicine is not approved for use in children.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • alcohol or any product that contains alcohol

This medicine may also interact with the following medications:

  • antihistamines for allergy, cough and cold
  • atropine
  • barbiturates, like phenobarbital
  • cimetidine
  • diuretics
  • ipratropium
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • medicines for bladder problems like oxybutynin, tolterodine
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for Parkinson's disease like benztropine, trihexyphenidyl
  • medicines for sleep
  • muscle relaxants
  • naltrexone, naloxone
  • narcotic medicines (opiates) for pain
  • some medicines for stomach problems like dicyclomine, hyoscyamine
  • some medicines for travel sickness like scopolamine
  • tramadol

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Last Updated: August 24, 2012
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