medroxyPROGESTERone (generic name)

Cycrin (brand name)

It is commonly used to prevent the uterine lining from overgrowth in women taking an estrogen after menopause
(me DROX ee proe JES te rone)
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What is this medicine?

MEDROXYPROGESTERONE (me DROX ee proe JES te rone) is a hormone in a class called progestins. It is commonly used to prevent the uterine lining from overgrowth in women taking an estrogen after menopause. It is also used to treat irregular menstrual bleeding or a lack of menstrual bleeding in women.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • blood vessel disease or a history of a blood clot in the lungs or legs
  • breast, cervical or vaginal cancer
  • heart disease
  • kidney disease
  • liver disease
  • migraine
  • recent miscarriage or abortion
  • mental depression
  • migraine
  • seizures (convulsions)
  • stroke
  • vaginal bleeding that has not been evaluated
  • an unusual or allergic reaction to medroxyprogesterone, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. While this drug may be prescribed for children as young as 13 years for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

  • barbiturate medicines for inducing sleep or treating seizures (convulsions)
  • bosentan
  • carbamazepine
  • phenytoin
  • rifampin
  • St. John's Wort

What should I watch for while using this medicine?

Visit your health care professional for regular checks on your progress. You will need a regular breast and pelvic exam.

If you have any reason to think you are pregnant, stop taking this medicine at once and contact your doctor or health care professional.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • breast tenderness or discharge
  • changes in mood or emotions, such as depression
  • changes in vision or speech
  • pain in the abdomen, chest, groin, or leg
  • severe headache
  • skin rash, itching, or hives
  • sudden shortness of breath
  • unusually weak or tired
  • yellowing of skin or eyes

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • acne
  • change in menstrual bleeding pattern or flow
  • changes in sexual desire
  • facial hair growth
  • fluid retention and swelling
  • headache
  • upset stomach
  • weight gain or loss

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Last Updated: December 17, 2009
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