lubiprostone (generic name)

Amitiza (brand name)

It is used to treat chronic constipation and constipation caused by opioids (certain prescription pain medicines)
(loo bi PROS tone)
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What is this medicine?

LUBIPROSTONE (loo bi PROS tone) is a laxative. It is used to treat chronic constipation and constipation caused by opioids (certain prescription pain medicines). It is also used to treat adult women with irritable bowel syndrome who have constipation.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • cancer or tumor in abdomen, intestine, or stomach
  • history of bowel obstruction or adhesions
  • history of stool (fecal) impaction
  • liver disease
  • an unusual or allergic reaction to lubiprostone, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush or chew this medicine. Take this medicine with food. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

  • medicines that treat diarrhea
  • methadone
  • other medicines for constipation

What should I watch for while using this medicine?

Visit your doctor for regular check ups. Tell your doctor if your symptoms do not get better or if they get worse.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • new or worsening stomach pain
  • severe or prolonged diarrhea

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • headache
  • loose stools
  • nausea

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Last Updated: April 26, 2013
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