lomustine (generic name)

It interferes with the growth of rapidly growing cells like cancer cells
(loe MUS teen)
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What is this medicine?

LOMUSTINE (loe MUS teen) is a chemotherapy drug. It interferes with the growth of rapidly growing cells like cancer cells. This medicine is used to treat brain tumors and Hodgkin's disease.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • infection (especially a virus infection such as chickenpox, cold sores, or herpes)
  • low blood counts like low platelets, red blood cells, or white blood cells
  • lung disease
  • an unusual or allergic reaction to lomustine, CCNU, other chemotherapy, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Wear impervious gloves when handling this medicine. Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. To provide the correct dose for you, there may be capsules of different sizes and colors to take as a single dose. Make sure you understand how to take your dose. This medicine is usually taken as a single dose once every 6 weeks. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

It is important not to miss your dose. Call your doctor or health care professional for directions if you are unable to take your dose or if you miss your dose.

What may interact with this medicine?

  • cimetidine
  • medicines to increase blood counts like filgrastim, pegfilgrastim, sargramostim
  • vaccines

Talk to your doctor or health care professional before taking any of these medicines:

  • acetaminophen
  • aspirin
  • ibuprofen
  • ketoprofen
  • naproxen

What should I watch for while using this medicine?

Visit your doctor for checks on your progress. This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

This medicine is taken only every 6 weeks. You may need to wait longer between doses if you have low blood counts. Your doctor will order blood work to check your blood count and to monitor your condition.

In some cases, you may be given additional medicines to help with side effects. Follow all directions for their use.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

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Last Updated: June 22, 2009
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