lepirudin (generic name)

It is used in a hospital setting to help prevent blood clots
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What is this medicine?

LEPIRUDIN is an anticoagulant. It is used in a hospital setting to help prevent blood clots.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • bleeding disorders or hemophilia
  • high blood pressure
  • infection of the heart valves
  • kidney disease
  • liver disease
  • lumbar puncture or spinal anesthesia
  • recent surgery or trauma
  • stomach or intestinal ulcers
  • weak or unstable blood vessels
  • an unusual or allergic reaction to lepirudin, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection or infusion into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • aspirin and aspirin-like medicines
  • medicines that treat or prevent blood clots like warfarin or heparin
  • mifepristone

This medicine may also interact with the following medications:

  • abciximab
  • cilostazol
  • clopidogrel
  • dipyridamole
  • eptifibatide
  • lamifiban
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • ticlopidine
  • tirofiban

What should I watch for while using this medicine?

Monitor your skin closely for easy bruising or red spots. Tell your doctor or health care professional if you notice any unusual bruising or bleeding.

Be careful to avoid injury while you are receiving this medicine. Take special care brushing or flossing your teeth. Report any injuries to your doctor or health care professional.

If you are going to have surgery, tell your doctor or health care professional that you have received this medicine.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • back or stomach pain
  • black, tarry stools
  • blood in urine
  • breathing problems
  • coughing up blood
  • feeling faint or lightheaded, falls
  • heavy menstrual bleeding
  • nosebleeds
  • unusual bleeding or bruising

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • irritation at site where injected

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Last Updated: June 23, 2009
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