itraconazole (generic name)

Sporanox (brand name)

It is used to treat certain kinds of fungal or yeast infections
(i tra KO na zole)
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What is this medicine?

ITRACONAZOLE (i tra KO na zole) is an antifungal medicine. It is used to treat certain kinds of fungal or yeast infections.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • heart disease, including angina or heart failure
  • kidney disease or on dialysis
  • liver disease
  • lung disease
  • an unusual or allergic reaction to itraconazole, or other antifungal medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection into a vein. It is usually given by a health care professional in a hospital or clinic setting.

If you get this medicine at home, you will be taught how to prepare and give this medicine. Use exactly as directed. Take your medicine at regular intervals. Do not take it more often than directed.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • alfuzosin
  • cisapride
  • ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
  • nevirapine
  • nisoldipine
  • pimozide
  • red yeast rice
  • sirolimus
  • some medicines for anxiety or sleep like alprazolam, clorazepate, flurazepam, midazolam, triazolam
  • some medicines for cancer treatment
  • some medicines for cholesterol like atorvastatin, cerivastatin, lovastatin, simvastatin
  • some medicines for the heart like conivaptan, dofetilide, eplerenone, quinidine, ranolazine

This medicine may also interact with the following medications:

  • alfentanil
  • antiviral medicines for HIV or AIDS
  • budesonide
  • buspirone
  • cilostazol
  • cyclosporine
  • digoxin
  • disopyramide
  • eletriptan
  • erythromycin
  • fentanyl
  • fluticasone
  • halofantrine
  • medicines for blood pressure like amlodipine, felodipine, nifedipine
  • medicines for stomach problems like cimetidine, famotidine, omeprazole, lansoprazole
  • medicines for tuberculosis like isoniazid, INH, rifabutin, rifampin, rifapentine
  • medicines that treat or prevent blood clots like warfarin
  • methylprednisolone
  • other medicines for fungal infections
  • phenytoin, fosphenytoin
  • some medicines for diabetes
  • tacrolimus
  • trimetrexate

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. If you are taking this medicine for a long time you may need blood work. Some fungal infections need many weeks or months of treatment to cure.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • changes in hearing
  • cough up mucus
  • dark urine
  • fast, irregular heartbeat
  • general ill feeling or flu-like symptoms
  • light-colored stools
  • loss of appetite
  • nausea, vomiting
  • pain at site where injected
  • pain, tingling, numbness in the hands or feet
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • right upper belly pain
  • sudden weight gain
  • swelling in feet, ankles, or legs
  • unusually weak or tired
  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea
  • dizziness
  • headache
  • stomach upset or bloating

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Last Updated: May 05, 2009
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