isoniazid-rifampin (generic name)

It is used to treat tuberculosis (TB)
(eye soe NYE a zid; RIF am pin)
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What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. You will need blood work done regularly.

You may need to take vitamin supplements while on this medicine. Talk to your doctor about the foods you eat and the vitamins you take. Avoid taking antacids containing aluminum, calcium or magnesium, and iron-containing products within 2 hours of taking this medicine. It is best to separate these medicines by 4 to 6 hours.

If you are diabetic, monitor your blood sugars closely. This medicine may change the way your diabetic medicine works, and sometimes will require that your dosages be adjusted. Check with your doctor or health care professional.

If you have diabetes, you may get a false-positive result for sugar in your urine. Check with your doctor or health care professional.

This medicine can cause serious liver problems. Make sure you understand the risks for liver problems and how to identify the symptoms. If you have any questions, talk with your doctor or other health care provider.

Avoid alcoholic drinks while you are taking this medicine. Drinking alcohol during treatment with this medicine increases the risk of serious liver problems.

Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control.

This medicine can color your urine, feces (stool), perspiration (sweat), tears, sputum, skin or saliva reddish-orange to reddish-brown. This color can last for as long as you take this medicine and is not a cause for alarm. This color in tears may permanently stain soft contact lenses. It is better not to wear soft contact lenses while you are taking this medicine.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • changes in vision or eye pain
  • dark urine
  • feeling faint or lightheaded, falls
  • fever or chills, sore throat
  • hallucination, loss of contact with reality
  • loss of appetite
  • memory problems
  • nausea, vomiting
  • pain, tingling, numbness in the hands or feet
  • pinpoint red spots on the skin
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • seizures
  • stomach pain
  • trouble passing urine or change in the amount of urine
  • unusual bleeding, bruising
  • unusually weak or tired
  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (Report these to your doctor or health care professional if they continue or are bothersome.):

  • breast enlargement or tenderness
  • diarrhea
  • headache
  • loss of appetite
  • upset stomach
  • trouble sleeping

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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Last Updated: May 31, 2011
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