insulin lispro-insulin lispro protamine (generic name)

Humalog Mix 50/50 (brand name)

This drug lowers the amount of sugar in your blood
(IN su lin LYE sproe; IN su lin LYE sproe PRO ta meen)
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What is this medicine?

INSULIN LISPRO; INSULIN LISPRO PROTAMINE (IN su lin LYE sproe; IN su lin LYE sproe PRO ta meen) is a human-made form of insulin. This drug lowers the amount of sugar in your blood. This medicine is a mixture of a rapid-acting insulin and a longer-acting insulin. It starts working quickly after injection and continues to work for as long as 12 to 24 hours.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • episodes of hypoglycemia
  • kidney disease
  • liver disease
  • an unusual or allergic reaction to insulin, metacresol, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection under the skin. Use exactly as directed. It is important to follow the directions given to you by your health care professional or doctor. You should inject this medicine within 15 minutes before or after your meal. You will be taught how to use this medicine and how to adjust doses for activities and illness. Do not use more insulin than prescribed. Do not use more or less often than prescribed.

Always check the appearance of your insulin before using it. This medicine should be white and cloudy. Do not use it if is not uniformly cloudy after mixing. To mix this medicine, roll the vial gently 10 times in your hands. If using the Humalog Mix disposable pen, roll the pen gently 10 times in your hands. Then, turn the pen upside down so that the glass ball moves from one end of the pen to the other. Do this at least 10 times. Make sure to perform the mixing procedures before each injection. In addition, the pen should be primed before each injection. Your doctor or diabetes educator will teach you how to use the pen.

Do not mix this medicine with any other insulin or diluent.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

It is important not to miss a dose. Your health care professional or doctor should discuss a plan for missed doses with you. If you do miss a dose, follow their plan. Do not take double doses.

What may interact with this medicine?

  • other medicines for diabetes

Many medications may cause an increase or decrease in blood sugar, these include:

  • alcohol containing beverages
  • aspirin and aspirin-like drugs
  • chloramphenicol
  • chromium
  • diuretics
  • female hormones, like estrogens or progestins and birth control pills
  • heart medicines
  • isoniazid
  • male hormones or anabolic steroids
  • medicines for weight loss
  • medicines for allergies, asthma, cold, or cough
  • medicines for mental problems
  • medicines called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl
  • niacin
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • pentamidine
  • phenytoin
  • probenecid
  • quinolone antibiotics like ciprofloxacin, levofloxacin, ofloxacin
  • some herbal dietary supplements
  • steroid medicines like prednisone or cortisone
  • thyroid medicine

Some medications can hide the warning symptoms of low blood sugar. You may need to monitor your blood sugar more closely if you are taking one of these medications. These include:

  • beta-blockers such as atenolol, metoprolol, propranolol
  • clonidine
  • guanethidine
  • reserpine

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Last Updated: March 20, 2009
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