hydrochlorothiazide-spironolactone (generic name)

It helps you make more urine and lose excess water from your body
(hye droe klor oh THYE a zide; speer on oh LAK tone)
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What is this medicine?

HYDROCHLOROTHIAZIDE; SPIRONOLACTONE (hye droe klor oh THYE a zide; speer on oh LAK tone) is a combination of two types of diuretics. It helps you make more urine and lose excess water from your body. This medicine is used to treat high blood pressure and water retention from heart, kidney, or liver disease.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • diabetes
  • immune system problems, like lupus
  • kidney disease
  • liver disease
  • an unusual reaction to hydrochlorothiazide, spironolactone, sulfa drugs, other medicines, foods, dyes, or preservatives
  • breast-feeding
  • pregnant or trying to get pregnant

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Remember that you will need to pass urine frequently after taking this medicine. Do not take your doses at a time of day that will cause you problems. Do not take at bedtime. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • ACE inhibitors like captopril, lisinopril
  • eplerenone
  • lithium
  • medicine for pain and inflammation like indomethacin
  • other diuretics
  • potassium supplements

This medicine may also interact with the following medications:

  • alcohol
  • barbiturate medicines for sleep or seizure control
  • digoxin
  • medicines for diabetes
  • medicines for high blood pressure or heart failure
  • muscle relaxers
  • neuromuscular blockers used during surgery
  • some medicines for pain like codeine
  • steroid hormones like cortisone, hydrocortisone, prednisone

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor what your blood pressure should be, and when you should contact them. If you are diabetic, check your blood sugar as directed.

You must not get dehydrated. Ask your doctor or health care professional how much fluid you need to drink a day. Check with him or her if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

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Last Updated: September 01, 2011
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