glimepiride-pioglitazone (generic name)

Duetact (brand name)

It helps to control blood sugar
(GLYE me pye ride; pye oh GLI ta zone)
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What is this medicine?

GLIMEPIRIDE; PIOGLITAZONE (GLYE me pye ride; pye oh GLI ta zone) helps to treat type 2 diabetes. It helps to control blood sugar. Treatment is combined with diet and exercise.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • bladder cancer
  • diabetic ketoacidosis
  • glucose-6-phosphate dehydrogenase deficiency
  • heart disease
  • kidney disease
  • liver disease
  • severe infection or injury
  • swelling of the arms, legs, or feet
  • thyroid disease
  • an unusual or allergic reaction to glimepiride, pioglitazone, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

  • aspirin and aspirin-like medicines
  • atorvastatin
  • bosentan
  • chloramphenicol
  • clarithromycin
  • diuretics
  • female hormones, like estrogens and birth control pills
  • gemfibrozil
  • isoniazid
  • ketoconazole
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • medicines for cold or congestion
  • medicines for high blood pressure like metoprolol, propanolol
  • medications for weight loss
  • methotrexate
  • miconazole
  • midazolam
  • nifedipine
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • other medicines for diabetes
  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
  • phenytoin
  • probenecid
  • rifampin
  • steroid medicines like prednisone or cortisone
  • thyroid hormones
  • warfarin

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Learn how to check your blood sugar. Tell your doctor or health care professional if your blood sugar is high, you might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine. Do not skip meals. Ask your doctor or health care professional if you should avoid alcohol. If you have symptoms of low blood sugar, eat or drink something containing sugar at once and contact your doctor or health care professional. Make sure family members know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, like seizures or unconsciousness. They must get medical help at once.

Wear a medical identification bracelet or chain to say you have diabetes, and carry a card that lists all your medications.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

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Last Updated: August 08, 2011
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