estradiol-norethindrone transdermal (generic name)

This medicine helps to relieve the symptoms of menopause like hot flashes, night sweats, mood changes, and vaginal dryness and irritation
(es tra DYE ole; nor eth IN drone)
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What is this medicine?

ESTRADIOL; NORETHINDRONE (es tra DYE ole; nor eth IN drone) contains a mixture of female hormones. This medicine helps to relieve the symptoms of menopause like hot flashes, night sweats, mood changes, and vaginal dryness and irritation. It is also used to treat women with low estrogen levels or those who have had their ovaries removed.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • blood vessel disease or blood clots
  • breast, cervical, endometrial, or uterine cancer
  • diabetes
  • endometriosis
  • fibroids
  • gallbladder disease
  • heart disease or recent heart attack
  • high blood cholesterol
  • high blood pressure
  • high level of calcium in the blood
  • hysterectomy
  • kidney disease
  • liver disease
  • mental depression
  • migraine headaches
  • porphyria
  • stroke
  • systemic lupus erythematosus (SLE)
  • tobacco smoker
  • vaginal bleeding
  • an unusual or allergic reaction to estrogens, progestins, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for external use only. Follow the directions on the prescription label. Use exactly as directed. Tear open the pouch, do not use scissors. Remove the stiff protective liner covering the adhesive. Try not to touch the adhesive. Apply the patch, sticky side to the skin, to an area of the lower abdomen that is clean, dry and hairless. Avoid injured, irritated, calloused, or scarred areas. Do not apply the skin patches to your breasts or around the waist area. Use a different site each time to prevent skin irritation. You should change your patch on the same days each week. Do not cut or trim the patch. Do not stop using except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

What if I miss a dose?

If you forget to change your patch as scheduled, apply it as soon as possible. Remember to remove the old patch. If it is almost time to apply the next patch, skip the missed patch and get back on your normal schedule. Do not wear more than one patch at a time unless you are told to do so by your doctor or health care professional.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medicine may also interact with the following medications:

  • barbiturates, such as phenobarbital
  • benzodiazepines
  • bosentan
  • bromocriptine
  • carbamazepine
  • cimetidine
  • cyclosporine
  • dantrolene
  • grapefruit juice
  • griseofulvin
  • hydrocortisone, cortisone, or prednisolone
  • isoniazid (INH)
  • medications for diabetes
  • methotrexate
  • mineral oil
  • phenytoin
  • raloxifene
  • rifabutin, rifampin, or rifapentine
  • tamoxifen
  • thyroid hormones
  • topiramate
  • tricyclic antidepressants
  • warfarin

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Last Updated: December 03, 2009
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