estradiol topical (generic name)

Divigel 0.25 mg/packet (brand name)

It is mostly used as hormone replacement in menopausal women
(es tra DYE ole)
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What is this medicine?

ESTRADIOL (es tra DYE ole) is an estrogen. It is mostly used as hormone replacement in menopausal women. This medicine helps relieve symptoms of menopause such as hot flashes, night sweats, and mood changes.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • abnormal vaginal bleeding
  • blood vessel disease or blood clots
  • breast, cervical, endometrial, ovarian, liver, or uterine cancer
  • dementia
  • diabetes
  • gallbladder disease
  • heart disease or recent heart attack
  • high blood pressure
  • high cholesterol
  • high level of calcium in the blood
  • hysterectomy
  • kidney disease
  • liver disease
  • migraine headaches
  • protein C deficiency
  • protein S deficiency
  • stroke
  • systemic lupus erythematosus (SLE)
  • tobacco smoker
  • an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for external use only. Follow the directions on the prescription label. Your health care provider will show you how to apply this medicine. Apply this medicine at the same time each day to clean, dry, unbroken skin on the inside of the forearm between the elbow and the wrist. If you take a bath or shower or use a sauna, apply this medicine after the bath, shower, or sauna, and once the skin is dry. Avoid fire, flame or smoking until the spray has dried. Do not apply to the breast. Do not use your medicine more often than directed.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, skip the missed dose and get back on your normal schedule. Do not use double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medicine may also interact with the following medications:

  • antibiotics used to treat tuberculosis like rifabutin, rifampin and rifapentine
  • antiviral medicines for HIV or AIDS
  • certain antibiotics like erythromycin and clarithromycin
  • carbamazepine
  • grapefruit juice
  • medicines for fungal infections like ketoconazole and itraconazole
  • phenobarbital
  • raloxifene
  • tamoxifen
  • St. John's Wort

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Last Updated: March 21, 2012
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