erythromycin-sulfisoxazole (generic name)

It is used to treat certain kinds of bacterial infections
(er ith roe MYE sin, sul fi SOX a zole)
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What is this medicine?

ERYTHROMYCIN, SULFISOXAZOLE (er ith roe MYE sin, sul fi SOX a zole) is combination of a macrolide and a sulfonamide antibiotic. It is used to treat certain kinds of bacterial infections. It It will not work for colds, flu, or other viral infections.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • asthma
  • glucose-6-phosphate dehydrogenase (G6PD) deficiency
  • kidney disease
  • liver disease
  • myasthenia gravis
  • an unusual or allergic reaction to erythromycin, sulfisoxazole, sulfa drugs, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with glass of water. Follow the directions on the prescription label. Shake well before using. Use a specially marked spoon, or container to measure the medicine. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not skip doses or stop your medicine early even if you feel better. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 2 months of age for selected conditions, precautions do apply. Do not use in children under 2 months old.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • arsenic trioxide
  • cisapride
  • dihydroergotamine, ergotamine
  • droperidol
  • grepafloxacin
  • medicines for cholesterol like lovastatin, simvastatin
  • medicines for heart rhythm like disopyramide, dofetilide
  • mesoridazine
  • pimozide
  • ranolazine
  • red yeast rice
  • sparfloxacin
  • thioridazine
  • vinblastine
  • ziprasidone

This medicine may also interact with the following medications:

  • bromocriptine
  • carbamazepine
  • cilostazol
  • cyclosporine
  • digoxin
  • medicines for anxiety or sleep like alprazolam, triazolam
  • medicines for diabetes
  • medicines for seizures like hexobarbital and phenytoin
  • methotrexate
  • methylprednisolone
  • other antibiotics
  • quinidine
  • sildenafil, vardenafil
  • tacrolimus
  • theophylline
  • warfarin

What should I watch for while using this medicine?

Tell your doctor or health care professional if your symptoms do not improve or if they get worse.

Do not treat diarrhea with over the counter products. Contact your doctor if you have diarrhea that lasts more than 2 days or if it is severe and watery.

Drink several glasses of water a day as directed. You must not get dehydrated.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • confused, dizzy, trouble walking
  • dark urine
  • difficulty breathing, cough
  • fever, flu like symptoms, sore throat
  • hearing loss
  • increased sensitivity to the sun or ultraviolet light
  • irregular heartbeat, feeling faint
  • low blood sugar
  • pain or difficulty passing urine
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • unusual bruising, bleeding
  • unusually weak or tired
  • yellowing of eyes, skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea
  • headache
  • loss of appetite
  • nausea, vomiting
  • stomach upset

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Last Updated: April 20, 2009
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