colistimethate (generic name)

It is used to treat certain kinds of bacterial infections
(koe lis ti METH ate, koe LIS tin, pol i MIX in E)
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What is this medicine?

COLISTIMETHATE, COLISTIN, POLYMYXIN E (koe lis ti METH ate, koe LIS tin, pol i MIX in E) is a polymyxin antibiotic. It is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • balance problems
  • kidney disease
  • myasthenia gravis
  • Parkinson's disease
  • an unusual or allergic reaction to colistimethate, colistin, polymyxin, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection into a muscle or infusion into a vein. It is usually given by a health care professional in a hospital or clinic setting.

If you get this medicine at home, you will be taught how to prepare and give this medicine. Use exactly as directed. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think you are better. Do not skip doses or stop your medicine early.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

This medicine may interact with the following medications:
  • anesthesia drugs
  • cephalothin
  • cisplatin
  • cyclosporine
  • medicines for infection like acyclovir, adefovir, amikacin, amphotericin B, bacitracin, cidofovir, foscarnet, ganciclovir, gentamicin, kanamycin, pentamidine, polymyxin B, streptomycin, tobramycin, vancomycin,
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • pamidronate
  • zoledronic acid

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

Tell your doctor or health care professional if you have any problems passing urine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you.

Do not treat diarrhea with over the counter products. Contact your doctor if you have diarrhea that lasts more than 2 days or if it is severe and watery.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • burning, numbness, tingling
  • confused, dizzy, disoriented
  • fever
  • loss of balance
  • trouble passing urine or change in the amount or color of urine
  • white patches or sores in the mouth

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea
  • pain at site where injected

Where should I keep my medicine?

Keep out of the reach of children.

If you are using this medicine at home, you will be instructed on how to store this medicine. Throw away any unused medicine after the expiration date on the label.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Last Updated: April 06, 2009
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